骨髓间充质干细胞（bone marrow mesenchymalstem cells，BMSCs）是骨髓中除了造血干细胞之外的另一种干细胞，在特定的诱导因素诱导下BMSCs能够向成骨细胞、脂肪细胞、肌细胞、神经细胞等细胞分化，同时其可在体外培养条件下进行增殖、诱导和分化。目前，BMSCs在组织工程、细胞治疗等相关领域有着广泛的应用前景。

[1] FRIEDENSTEIN A J,GORSKAJA U,KULAGINA N N.Fiberoblast precursors in normal and irradiated mouse hematopoietic organs[J].Exp Hematol,1976,4(5):267-274.
[2] 潘欣宇,崔颖,马林祥.骨髓间充质干细胞的研究进展及临床应用前景[J].中国医学工程,2011,19(5):173-176.
[3] 张卫东,史宏灿,章方彪.兔骨髓间充质干细胞体外培养方法的比较[J].中华实验外科杂志,2013,30(7):1360-1363.
[4] 杨玉霞,郑健樑,张平.密度梯度离心结合贴壁法培养成年大鼠骨髓间充质干细胞的生物学特性[J].中国组织工程研究与临床康复,2007,11(3):583-586.
[5] 张蓉,沈开金,刘彦普.兔骨髓间充质干细胞的体外培养及多向诱导分化[J].中国组织工程研究与临床康复,2010,14(45):8382-8385.
[6] COLTER D C,CLASS R,DIGIROLAMO C M,et al.Rapidexpan of recycling stemcells in cultures of plsstic adherent cells from human bone marrow[J].Proc Nat Acid Sci USA,2000,97(7):3213-3218.
[7] CONGET P A,MINGUELL J J.Phenotypicaland functional properties of human bonemarrow mesenchymal progenitor cells[J].J Cell Physiol,1999,181(1):67-73.
[8] 刘剑伟,肖增明.骨髓间充质干细胞在骨科组织工程中的应用[J].中国组织工程研究与临床康复,2007,11(46):9375-9378.
[9] 郭峰,张翠.骨髓间充质干细胞的研究进展[J].疑难病杂志,2010,9(5):393-394.
[10] 王庆贤,张英泽,马哲,等.骨髓间充质干细胞研究进展[J].中华实验外科杂志,2003,20(6):575-576.
[11] 邱林,金先庆.骨髓间充质干细胞的生物学特性及其临床治疗应用[J].中国组织工程研究与临床康复,2008,12(12):2347-2350.
[12] 潘欣宇,崔颖,马林祥,et al.骨髓间充质干细胞的研究进展及临床应用前景[J].中国医学工程,2011,19(5):173-176.
[13] KRAMPERA M,GLENNIE S,DYSON J,et al.Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide[J].Blood,2003,101(9):3722-3729.
[14] GUO J,LIN G S.Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction[J].Inflammation,2007,30(3-4):97-104.
[15] AGGARWAL S,PITTENGER M F.Human mesenchymal stem cells modulate allogeneic immune cell responses[J].Blood,2005,105:1815-1822.
[16] DENG W,HAN Q,LIAO L,et al.Effects of allogeneic bone marrowderived mesenchymal stem cells on T and B lymphocytes from BXSB mice[J].DNA Cell Biol,2005,24:458-463.
[17] 傅文玉,路艳蒙,朴英杰.人骨髓间充质干细胞的培养及多能性研究[J].中华血液学杂志,2002,23(4):202-204.
[18] PROCKOP D J.Marrow stromal cell as stem eeUs for nonhematopoietie tissues[J].Science,1997,276(5309):71-74.
[19] PITTENGER M F,MAEKAY A M,BECK S C,et a1.Multilineage potential adult human mesenchymal stem cells .Science,1999,284(54 11 1:143-147.
[20] OUYANG H W,CAO T,ZOU X H.Mesenchymal stem cell sheets revitalize nonviable dense grafts:implications for repair of largebone and tendon defects[J].Transplantation 2006,82(2):170-174.
[21] 吴军,张燕燕.骨髓间充质干细胞生物学特性及临床应用进展[J].中国组织工程研究与临床康复,2007,11(50):10134-10137.
[22] 李彦林,韩睿,王福科.骨髓间充质干细胞在骨及软骨组织工程中的应用[J].中国临床康复,2006,10(5):121-124.
[23] 艾自明,任慧霞,罗俊永.生长因子对骨髓间充质干细胞增殖、分化的影响[J].生命的化学,2010,30(1):33-37.
[24] 倪明,王岩,李刚.骨髓间充质干细胞的成肌腱分化促进肌腱愈合的实验研究[D].北京:军医进修学院,2011.
[25] 李宁.低氧微环境对间充质干细胞增殖、分化影响的研究进展[J].重庆医学,2010,39(8):897-898.
[26] 张永强,杨自权,卫小春.骨髓间充质干细胞成软骨分化的影响因素研究进展[J].中华实验外科杂志,2011,28(7):1193-1194.
[27] MOUW J K,CONNELLY J T,WILSON C G.Dynamic compression regulates the expression and synthesis of chondrneyte-specific matrix molecules in bone marrow strnmal[J].Cells,2007,25:655-663.
[28] OVIC L D,VARGA I,ZAMBOREKY' R,et al.The tissue engineering of articular cartilage:cells,scaffolds and stimulating factors[J].Exp Biol Med,2012,237:10-17.
[29] 张韬,祝少博,喻爱喜.hTGF-β1基因修饰BMSCs复合藻酸钙凝胶三维培养构建组织工程化软骨[J].中华显微外科杂志,2012,35(1):40-45,97.
[30] BORDEN M,ATTAWIA M,KHAN Y,et al.Tissue-engineered bone formation in vivo using a novel sintered polymeric microsphere matrix[J].J Bone Joint Surg Br,2004,86(B):1200-1208.
[31] QUARTO R,MASTROGIAEOMO M,CANEEDDA R,et al.Repair of large bone defects by autologous human bone marrow stromal cells[J].N EngI J Med,2001,344(5):385-386.
[32] WAKITANI S,GOTO T,PINEDA S J.Mesenchymal cell-based repair of large, full thickness defects of articular cartilage[J]. J Bone Joint Surg Am,1994(4):579-592.
[33] YOO J U,MANDEU L,ANGELE P,et al.Chondrogenitor cells and gene therapy[J].Clin Orthop,2000,379(suppl):64-70.
[34] 谭洪波,杨柳.局部关节软骨和骨软骨损伤修复策略的研究进展[J].中华关节外科杂志,2012,4(6):795-802.
[35] 崔凤鸣,朱海涛,包善华,等.骨髓间充质干细胞作为胰腺癌基因治疗载体的实验研究[J].现代医学,2011,39(4):387-392.