Objective: To investigate the changes of heme oxygenase-1(HO-1),insulin-like growth factor-1(IGF-1) in healthy macrosomia placenta and macrosomia of gestational diabetic placenta and it's significance.Methods: Sixty healthy full-term neonates were chosen and 12 cases of macrosomias who's mothers were gestational diabetes mellitus(GDM) patients as macrosomia group A,18 cases of macrosomias who's mothers were healthy as macrosomia group B,30 cases of normal birth weight neonates were as control group.The expression of HO-1,IGF-1 in placenta tissue were detected by the method of immunohistochemistry,the levels of HO-1,IGF-1 in placenta tissue were measured by enzyme linked immunosorbent assay.Results:The intensity of HO-1,IGF-1 expression in placenta of both macrosomia group A and macrosomia group B were higher than at in control group(all P<0.05),the comparison of HO-1,IGF-1 levels in plaecnta of both macrosomia group A and macrosomia group B were higher than at in control group(all P<0.05).There were no significant difference was found between macrosomia group A and macrosomia group B(P>0.05).Both macrosomia group A and macrosomia group B,the significant positve correlations were observed between levels of HO-1 and levels of IGF-1(P<0.05).Conclusion: The expression levels of placental HO-1,IGF-1 may have relationship with macrosomias. |
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