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Analysis of pathogenesis and risk factors associated with retinopathy of prematurity
作者：SWASTIK BIMB1  JIANG LI2 
单位：1. School of Medicine, South East University, Nanjing 210009, China;
2. Department of Pediatrics, Zhongda Hospital, South East University, Nanjing 210009, China
关键词：retinopathy of prematurity pathogenesis risk factor review article 
分类号：R722.6
出版年·卷·期（页码）：2014·33·第四期（517-523）
摘要：

Retinopathy of prematurity(ROP)is a disease associated with the vasculogenesis of the developing retina and in particular, in preterm newborns. The long term visual outcome of this disease includes increased risk of blindness and visual disabilities. The increasing prevalence of ROP, the leading cause of blindness in infants, necessitates the implementation of preventive measures to halt this trend, and this, most certainly, calls for the thorough understanding of the pathogenesis and various risk factors associated with the disease. Risk factors for ROP are among the main targets for improving health outcomes. Angiogenic factors including VEGF and IGF-1, maternal factors, oxidative stress and others(erythropoietin and inflammatory cytokines) are among the few of the most important risk factors that need to be addressed. A growing body of evidence suggests that subjects with ROP who have prenatal or postnatal risk factors are at increased risk of more severe ROP. These consistent observations have given rise to hopes of identifying the potential new risk factors and coming up with more efficient prevention and therapeutic strategies. However, studies focusing on incidence rates of ROP over time have painted an inconsistent picture. Individual studies have unequivocally demonstrated an association with the aforementioned risk factors, whereas epidemiological data however, is at best inconclusive.We have tried to integrate the studies, past and present, to identify the pathogenesis and novel risk factors.

Retinopathy of prematurity(ROP)is a disease associated with the vasculogenesis of the developing retina and in particular, in preterm newborns. The long term visual outcome of this disease includes increased risk of blindness and visual disabilities. The increasing prevalence of ROP, the leading cause of blindness in infants, necessitates the implementation of preventive measures to halt this trend, and this, most certainly, calls for the thorough understanding of the pathogenesis and various risk factors associated with the disease. Risk factors for ROP are among the main targets for improving health outcomes. Angiogenic factors including VEGF and IGF-1, maternal factors, oxidative stress and others(erythropoietin and inflammatory cytokines) are among the few of the most important risk factors that need to be addressed. A growing body of evidence suggests that subjects with ROP who have prenatal or postnatal risk factors are at increased risk of more severe ROP. These consistent observations have given rise to hopes of identifying the potential new risk factors and coming up with more efficient prevention and therapeutic strategies. However, studies focusing on incidence rates of ROP over time have painted an inconsistent picture. Individual studies have unequivocally demonstrated an association with the aforementioned risk factors, whereas epidemiological data however, is at best inconclusive.We have tried to integrate the studies, past and present, to identify the pathogenesis and novel risk factors.
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