[1] LEE H B,LYKETSOS C G.Depression in Alzheimer's disease:heterogeneity and related issues[J].Biol Psychiatry,2003,54(3):353-362.
[2] JORM A F.History of depression as a risk factor for dementia:an updated review[J].Aust N Z J Psychiatry,2001,35(6): 776-781.
[3] BASSUK S S,BERKMAN L F,WYPIJ D. Depressive symptomatology and incident cognitive decline in an elderly community sample[J].Arch Gen Psychiatry,1998,55(12):1073-1081.
[4] AZNAR S,KNUDSEN G M. Depression and Alzheimer's disease:is stress the initiating factor in a common neuropathological cascade?[J]J Alzheimers Dis,2011,23(2):177-193.
[5] KOBAYASHI T,KATO S.Depression-dementia medius:between depression and the manifestation of dementia symptoms[J].Psychogeriatrics,2011,11(3):177-182.
[6] SCHMITT J A,WINGEN M,RAMAEKERS J G,et al.Serotonin and human cognitive performance[J].Curr Pharm Des,2006,12(20):2473-2486.
[7] TOHGI H,ABE T,TAKAHASHI S,et al.Indoleamine concentrations in cerebrospinal fluid from patients with Alzheimer type and Binswanger type dementias before and after administration of citalopram,a synthetic serotonin uptake inhibitor[J].J Neural Transm Park Dis Dement Sect,1995,9(2-3):121-131.
[8] LAI M K,TSANG S W,FRANCIS P T,et al.Postmortem serotoninergic correlates of cognitive decline in Alzheimer's disease[J].Neuroreport,2002,13(9):1175-1178.
[9] MOWLA A,MOSAVINASAB M,PANI A.Does fluoxetine have any effect on the cognition of patients with mild cognitive impairment? A double-blind,placebo-controlled,clinical trial[J].J Clin Psychopharmacol,2007,27(1):67-70.
[10] MOWLA A,MOSABINASAB M,HAGHSHENAS H,et al.Does serotonin augmentation have any effect on cognition and activities of daily living in Alzheimer's dementia? A double-blind,placebo-controlled clinical trial[J].J Clin Psychopharmacol,2007,27(5):484-487.
[11] NYTH A L,GOTTFRIES C G.The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders.A Nordic multicentre study[J].Br J Psychiatry,1990,157:894-901.
[12] FINKEL S I,MINTZER J E,DYSKEN M,et al.A randomized,placebo-controlled study of the efficacy and safety of sertraline in the treatment of the behavioral manifestations of Alzheimer's disease in outpatients treated with done pezil[J].Int J Geriatr Psychiatry,2004,19(1):9-18.
[13] POLLOCK B G,MULSANT B H,ROSEN J,et al.Comparison of citalopram,perphenazine,and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized,demented patients[J].Am J Psychiatry,2002,159(3):460-465.
[14] NYTH A L,GOTTFRIES C G,LYBY K,et al.A controlled multicenter clinical study of citalopram and placebo in elderly depressed patients with and without concomitant dementia[J].Acta Psychiatr Scand,1992,86(2):138-145.
[15] TARAGANO F E,LYKETSOS C G,MANGONE C A,et al.A double-blind,randomized,fixed-dose trial of fluoxetine vs.amitriptyline in the treatment of major depression complicating Alzheimer's disease[J].Psychosomatics,1997,38(3):246-252.
[16] MUNRO C A,LONGMIRE C F,DRYE L T,et al.Cognitive outcomes after sertaline treatment in patients with depression of Alzheimer disease[J].Am J Geriatr Psychiatry,2012,20(12):1036-1044.
[17] MUNRO C A,BRANDT J,SHEPPARD J M,et al.Cognitive response to pharmacological treatment for depression in Alzheimer disease:secondary outcomes from the depression in Alzheimer's disease study (DIADS) [J].Am J Geriatr Psychiatry,2004,12(5):491-498.
[18] NELSON R L,GUO Z,HALAGAPPA V M,et al.Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice[J].Exp Neurol,2007,205(1):166-176.
[19] DONG H,GOICO B,MARTIN M,et al.Modulation of hippocampal cell proliferation,memory,and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress[J].Neuroscience,2004,127(3):601-609.
[20] EGASHIRA N,MATSUMOTO Y,MISHIMA K,et al.Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization[J].Pharmacol Biochem Behav,2006,83(1):161-167.
[21] LYONS L,ELBELTAGY M,BENNETT G,et al.Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery[J].PLoS One,2012,7(1):e30010.
[22] COUTO F S,BATALHA V L,VALADAS J S,et al.Escitalopram improves memory deficits induced by maternal separation in the rat[J].Eur J Pharmacol,2012,695(1-3):71-75.
[23] PERERA T D,PARK S,NEMIROVSKAYA Y.Cognitive role of neurogenesis in depression and antidepressant treatment[J].Neuroscientist,2008,14(4):326-338.
[24] MALBERG J E,EISCH A J,NESTER E J,et al.Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus[J].J Neurosci,2000,20(24):9104-9110.
[25] SANTARELLI L,SAXE M,GROSS C,et al.Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants[J].Science,2003,301(5634):805-809.
[26] BIANCHI P,CIANI E,GUIDI S,et al.Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome[J].J Neurosci,2010,30(26):8769-8779.
[27] LYONS L,ELBELTAGY M,UMKA J,et al.Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy[J].Psychopharmacology(Berl),2011,215(1):105-115.
[28] MARLATT M W,POTTER M C,BAYER T A,et al.prolonged running,not fluoxetine treatment,increases neurogenesis,but does not alter neuropathology,in the 3xTg mouse model of alzheimer's disease[J].Curr Top Behav Neurosci,2013,15:313-340.
[29] SIEGEL G J,CHAUHAN N B.Neurotrophic factors in Alzheimer's and Parkinson's disease brain[J].Brain Res Brain Res Rev,2000,33(2-3):199-227.
[30] LINNARSSON S,BJORKLUND A,ERNFORS P.Learning deficit in BDNF mutant mice[J].Eur J Neurosci,1997,9(12):2581-2587.
[31] MU J S,LI W P,YAO Z B,et al.Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats[J].Brain Res,1999,835(2):259-265.
[32] ARANCIBIA S,SILHOL M,MOULIERE F,et al.Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats[J].Neurobiol Dis,2008,31(3):316-326.
[33] ELLIOTT E,ATLAS R,LANGE A,et al.Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 Kinase signalling mechanism[J].Eur J Neurosci,2005,22(5):1081-1089.
[34] NAGAHARA A H,MERRILL D A,COPPOLA G,et al.Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease[J].Nat Med,2009,15(3):331-337.
[35] BEZCHLIBNYK Y,YOUNG L T.The neurobiology of bipolar disorder:focus on signal transduction pathways and the regulation of gene expression[J].Can J Psychiatry,2002,47(2):135-148.
[36] SONG L,CHE W,MIN WEI W,et al.Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress[J].Pharmacol Biochem Behav,2006,83(2):186-193.
[37] TALER M,MIRON O,GIL A D,et al.Neuroprotective and procognitive effects of sertraline:in vitro and in vivo studies[J].Neurosci Lett,2013,550:93-97.
[38] KLYUBIN I,CULLEN W K,HU N W,et al.Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory[J].Mol Brain,2012,5:25.
[39] TUCKER S,AHL M,CHO H H,et al.RNA therapeutics directed to the non coding regions of APP mRNA,in vivo anti-amyloid efficacy of paroxetine,erythromycin,and Nacetyl cysteine[J].Curr Alzheimer Res,2006,3(3):221-227.
[40] KEOWKASE R,ABOUKHATWA M,LUO Y.Fluoxetine protects against amyloid-beta toxicity,in part via daf-16 mediated cell signaling pathway,in Caenorhabditis elegans[J].Neuropharmacology,2010,59(4-5):358-365.
[41] CIRRTO J R,DISABATO B M,RESTIVO J L,et al.Serotonin signaling is associated with lower amyloid-beta levels and plaques in transgenic mice and humans[J].Proc Natl Acad Sci U S A,2011,108(36):14968-14973.
[42] RILEY K P,SNOWDON D A,MARKESBERY W R.Alzheimer's neurofibrillary pathology and the spectrum of cognitive function:findings from the Nun Study[J].Ann Neurol,2002,51(5):567-577.
[43] RISSMAN R A,LEE K F,VALE W,et al.Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation[J].J Neurosci,2007,27(24):6552-6562.
[44] MARTISOVA E,AISA B,GUERENU G,et al.Effects of early maternal separation on biobehavioral and neuropathological markers of Alzheimer's disease in adult male rats[J].Curr Alzheimer Res,2013,10(4):420-432.
[45] BRIONES A,GAGNO S,MARTISOVA E,et al.Stress-induced anhedonia is associated with an increase in Alzheimer's disease-related markers[J].Br J Pharmacol,2012,165:897-907.
[46] CHADWICK W,MITCHELL N,CAROLL J,et al.Amitriptyline-mediated cognitive enhancement in aged 3xTg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity[J].PLoS One,2011,6:e21660.
[47] TODA N,KANEKO T,KOGEN H.Development of an efficient therapeutic agent for Alzheimer's disease:design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter[J].Chem Pharm Bull (Tokyo),2010,58:273-287. |
