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DNA损伤修复蛋白XRCC1的研究进展
作者:徐诚  严丽锋  王心如  顾爱华 
单位:南京医科大学 公共卫生学院, 江苏 南京 211100
关键词:X线修复交叉互补蛋白1 DNA修复 突变体 文献综述 
分类号:Q754
出版年·卷·期(页码):2014·33·第三期(376-380)
摘要:

X线修复交叉互补蛋白1(XRCC1)在碱基切除修复(BER)以及单链断裂损伤修复(SSBR)中起着支架蛋白的作用。XRCC1可以与多个DNA修复相关蛋白交互作用并招募到DNA损伤部位,最终完成DNA的修复。由于XRCC1在DNA修复通路的重要作用,主要突变体Arg194Trp、Arg280His 以及 Arg399Gln也被深入地研究。在本文中作者对XRCC1的结构、功能以及它的突变体在人类疾病发生中的作用作一概述。

参考文献:

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