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基于microRNA表达谱技术的肺纤维化研究进展
作者:李文超  张迎建  杨红 
单位:东南大学公共卫生学院, 环境医学工程教育部重点实验室, 江苏 南京 210009
关键词:microRNA 肺纤维化 调控机制 文献综述 
分类号:R563.4
出版年·卷·期(页码):2014·33·第三期(367-371)
摘要:

肺纤维化是一组由多种病因所引起的肺破坏性疾病,引发肺纤维化的原因有很多,如遗传因素、环境因素等,但是肺纤维化的发病机制仍不明确。由于microRNA(miRNA)参与细胞增殖、分化、凋亡等多种生物进程,其表达异常会导致组织器官的癌变及纤维化等疾病,因此miRNA对肺纤维化的基因表达调控日益成为研究的热点。在本文中作者对几类microRNA在肺纤维化发生中的作用机制以及临床应用的研究进展进行综述。

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