内皮祖细胞参与了内皮功能稳定性的维护以及血管新生的过程，实验室和临床研究均表明，冠状动脉粥样硬化性心脏病的发生与内皮祖细胞的数量减少和功能障碍有密切关系，而药物仅能部分逆转已经受损的内皮祖细胞。因此，基于该原理的内皮祖细胞疗法可以通过恢复内皮祖细胞数量及功能，改善损伤血管的功能以及参与血管新生。作者对内皮祖细胞在冠状动脉粥样硬化性心脏病中的作用及研究进展作一综述。

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