茵陈加味汤联合熊去氧胆酸治疗妊娠肝内胆汁淤积症62例-东南大学学报医学版

茵陈加味汤联合熊去氧胆酸治疗妊娠肝内胆汁淤积症62例

单位：1. 苏州市中医医院妇产科,江苏苏州 215003;
2. 苏州市中医医院生殖科,江苏苏州 215003;
3. 苏州市中医医院中医药研究所,江苏苏州 215003

分类号：R289.51;R714.25

出版年·卷·期（页码）：2014·33·第二期（159-161）

摘要：

目的：观察茵陈加味汤联合熊去氧胆酸治疗妊娠肝内胆汁淤积症（intrahepatic cholestasis of pregnancy，ICP）的疗效。方法：采用前瞻性研究方法，将2010年至2012年本院收治的妊娠肝内胆汁淤积症孕妇108例随机分为A、B两组，A组采用茵陈加味汤联合熊去氧胆酸治疗（62例），B组采用熊去氧胆酸治疗（46例）。比较两组治疗效果及妊娠结局。结果：治疗结束时，A组治疗后皮肤瘙痒评分及TBA、AST、ALT、CG值均降低，且较B组低。两组瘙痒评分和AST、ALT值比较差异有统计学意义（P<0.05），剖宫产率、产后出血率、羊水粪染率比较差异也有统计学意义（P<0.05）。结论：茵陈加味汤联合熊去氧胆酸治疗ICP能够提高ICP的疗效，值得临床推广。

Objective: to observe the efficacy of ursodeoxycholic acid combined with modified Artemisiae Scopariae decoction in the treatment for intrahepatic cholestasis of pregnancy. Methods: 108 cases with ICP had been chosen and randomly divided into two groups: the A group(the ursodeoxycholic acid combined with modified Artemisiae Scopariae decoction group,62 case) and the B group(the ursodeoxycholic acid group,46 case),the clinical effect were compared before and after traetment. Results: The reduction of itch score, AST,ALT of the A group were significantly decreased than that in the B group(P<0.05). The TBA, CG of the A group were decreased than in the B group. Comparing the two groups, the incident of Cesarean section, Postpartum hemorrhage and the incident of meconium-stained amniotic fluid were significant(P<0.05). Conclusion: It is effective to treat ICP with combination of ursodeoxycholic acid and modified Artemisiae Scopariae decoction injection.

参考文献：

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