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基于HPA轴的PTSD发病机制研究进展
作者:付婧1  文鹏1  王艳杰1  陆炜1  吕海芹2 
单位:1. 东南大学医学院 生物工程系, 江苏 南京 210009;
2. 东南大学医学院 人体解剖与组织胚胎学系, 江苏 南京 210009
关键词:创伤后应激障碍 下丘脑-垂体-肾上腺轴 促肾上腺皮质激素释放激素 糖皮质激素 文献综述 
分类号:R749.5
出版年·卷·期(页码):2014·33·第一期(95-99)
摘要:

下丘脑-垂体-肾上腺(HPA)轴是机体主要的神经内分泌应激反应系统,在人体的应激反应中发挥核心作用。HPA轴的功能改变在创伤后应激障碍(PTSD)患者的发病机制及临床表现中起到重要作用。作者主要就以HPA轴为基础的PTSD相关发病机制的研究进展进行综述,重点从激素水平、糖皮质激素受体水平以及相关基因的变化3个方面展开讨论。

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