环境颗粒物与多种环境相关疾病有关。越来越多的研究表明，表观遗传学在环境相关疾病的发生、发展中发挥着重要的作用。环境颗粒物可引起DNA甲基化、组蛋白修饰、染色质重塑和miRNAs表达等表观遗传学改变，这种改变往往发生在疾病产生的早期，因此对其进行研究不仅可以了解疾病的发病机制，而且还为疾病早期诊断和预防筛选可能的标志物。本文对大气颗粒物、富含金属颗粒物和纳米颗粒物等环境颗粒物的表观遗传学效应研究进展进行综述。

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