低位直肠癌新辅助放化疗后完全缓解病例的治疗策略分析-东南大学学报医学版

低位直肠癌新辅助放化疗后完全缓解病例的治疗策略分析

单位：江苏省中医院消化肿瘤外科, 江苏南京 210029

分类号：R735.37;R730.5

出版年·卷·期（页码）：2014·33·第一期（77-80）

摘要：

目的：探讨低位直肠癌新辅助放化疗后完全缓解病例的治疗策略。方法：对我院接受新辅助放化疗的147例Ⅱ、Ⅲ期低位直肠癌患者的临床、病理资料进行回顾性分析。结果：新辅助放化疗后125例（85.03%）获得症状缓解，14例（9.52%）术后病理完全缓解（病理分期为pT₀N₀M₀），其中5例行术后辅助化疗，未出现术后复发转移；其余9例未行术后治疗，有3例（33.3%）出现术后转移。结论：新辅助放疗可使低位直肠癌肿瘤缩小，临床症状大部分缓解，病理降期，部分患者可达到病理完全缓解，但对完全缓解病例，术后仍需行辅助化疗。

Objective: To discuss the treatment strategy of complete clinical response cases after neoadjuvant chemoradiotherapy in mid-low rectal cancer. Methods: The clinical and pathological data of 147 cases with stage 2 or 3 mid-low rectal cancer was analyzed during the period of Jan.2001 to Dec.2012. Result: 6 to 8 weeks after the chemoradiotherapy,86 cases had clinical syndrome response, and 16 had complete clinical response.14 cases had complete pathological response after surgery(the pathological studies showed pT₀N₀M₀),among which 5 cases had postoperation chemotherapy, and there were no recurrence. However, other 9 cases had no treatment after the surgery, and 3 of them had recurrence. Conclusion: The neoadjuvant radiotherapy could shrink the neoplasm, greatly release the clinical syndrome, and demote the pathological stage.Part of the patients could get complete response.But for those patients who got complete pathological response after surgery, they still had to accept postoperative chemotherapy.

参考文献：

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