Objective: To investigate the relationship between high sensitive C-reactive protein(hs-CRP),heart rate variability(HRV) and severity, prognosis of coronary artery disease(CAD).Methods:306 patients who had accomplished coronary angiography were analyzed and divided into four groups by Gensini scoring, the normal group(n=62),the minimal group(n=64),the moderate group(n=92),the severe group(n=88). Before CAG, all cases underwent 24 hour ambulatory electrocardiogram and serum hs-CRP were detected. Subsequently the clinical information was analyzed and compared. All patients were followed up and the major adverse cardiovascular and cerebral events(MACCE) were recorded for at least 12 months. Results: Compared with the normal group, the serum hs-CRP in the lesion group increased significantly, and showed statistical differences between normal, minimal, moderate and severe group(P<0.05,P<0.01).SDNN and SDANN indices had a decreasing trend with the extent and severity of coronary artery lesion, and showed statistical differences between moderate, severe group and normal, minimal group(P<0.05,P<0.01). RMSSD,PNN50,LP,HP indices decreased significantly in severe group and showed statistical differences between severe group and normal, minimal,moderate group(P<0.05,P<0.01).A total of 17 patients from moderate and severe groups suffered from MACCE during the follow-up. There was no statistical differences between patients with MACCE and those without MACCE(P >0.05).Conclusion:HRV and hs-CRP in serum are closely related to the severity of coronary artery lesions and may have a value in predicting the severity of coronary artery disease.
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