益气活血中药对中晚期胰腺癌放化疗疗效的影响-东南大学学报医学版

益气活血中药对中晚期胰腺癌放化疗疗效的影响

单位：1. 解放军251医院肿瘤科, 河北张家口 075000;
2. 解放军251医院普通外科, 河北张家口 075000

分类号：R735.9

出版年·卷·期（页码）：2014·33·第一期（5-8）

摘要：

目的：探讨益气活血中药对三维适形放疗联合吉西他滨化疗治疗中晚期胰腺癌疗效的影响。方法：将106例中晚期胰腺癌患者随机分成两组：A组48例，行三维适形放疗联合吉西他滨化疗；B组58例，在A组放化疗基础上给予益气活血中药。观察两组上消化道反应、腹泻、腹痛、骨髓抑制及生活质量改善情况，通过疗效评价法观察近期有效率，分析患者的1、2年生存率。结果：（1） B组上消化道反应、腹泻、腹痛、骨髓抑制及生活质量较A组明显改善（P<0.05）；（2） A、B组近期有效率分别为56.3%（27/48）、67.2%（39/58），两组差异具有统计学意义（P >0.05）；（3） 1、2年生存率A组分别为36.8%、16.6%，B组分别为75.3%、28.2%，总体生存率比较，B组优于A组（χ²=9.205，P=0.002）。结论：益气活血中药能减轻放化疗所致的消化道反应，提高临床有效率，延长患者1、2年生存期。

Objective: To investigate the effect of qi replenishing and blood circulation activating drugs(QRBCAD) on radiotherapy and chemotherapy for moderate and advanced pancreatic cancer. Methods: 106 cases of locally advanced pancreatic cancer patients were randomly divided into two groups,48 patients treated with radiotherapy and chemotherapy treatment as group A and 58 patients treated with the same therapy but with additional QRBCAD medication as the group B, and the effects in the two groups were compared. Upper gastrointestinal tract reaction,diarrhoea,abdominal pain,bone marrow suppression, and the quality of life were observed among the two groups, at the same time the recent effectiveness and 1,2 year survival rate were observed. Results: The reaction of upper gastrointestinal tract reaction,diarrhoea,abdominal pain,bone marrow suppression, and the quality of life improvement of the patients were all lower in group A than that of in group B(P<0.05).The short term effective rate in group A and B was 56.3% and 67.2% respectively(P >0.05).The 1 and 2 year survival rate in group A were 36.8%,16.6%, and in group B 75.3% and 28.2% respectively, significant difference(P<0.05) was found in comparison of the two groups. Conclusion: QRBCAD could alleviate the gastroenteric reaction caused by radio and chemotherapy, raise the clinical symptomatic effective rate of treatment, and prolong the 1 and 2 year survival rate of patients.

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