近年来,肠源性因素在急性胰腺炎继发感染中的重要性已被认识并确立.急性胰腺炎时,肠道屏障功能受损,肠道固有的细菌、微生物和内毒素移位到肠道外各器官、组织,加剧急性胰腺炎的病程.现就肠源性感染的发生机制、细菌移位途径及相应的对策作一综述.

[1] Schwarz M, THOMSEN J, MEYER H. Frequency and time course of pancreatis and extrapancreatic bacterial infection in experimental acute pancreatitis in rats. 2000(4). doi:10.1067/msy.2000.104116
[2] KAZANTSEV G B, HECHT D W, RAO R. Plasmid labeling confirms bacterical translocation in pancreatitis. 1994(1). doi:10.1016/0002-9610(94)90074-4
[3] FORTZIK T. Pancreatitis and nutrition:significance of the gastrointestinal tract and nutrition for septic complications, 2001(1)
[4] BERG R D. Translocation of enteric bacteria in health and disease, 1992(59)
[5] Garg P K, KHANNA S, BOHIDAR N P. Incidence,spectrum and antibiotic sensitivity pattern of bacterial infections among patients. 2001(19). doi:10.1046/j.1440-1746.2001.02589.x
[6] Moody F G, HALEY R D, MUNCY D M. Intestinal transit and bacterial translocation in obstructive pancreatitis, 1995(8)
[7] Souza L, SAMPIETRE S N, FIGUEIREDO S. Bacterial translocation in acute pancreatitis.Experimental study in rats, 1996(4)
[8] Isenmann R, SCHWARZ M, RAU B. Characteristics of infection with candida species in patients with necrotizing pancreatitis. 2002(3). doi:10.1007/s00268-001-0146-9
[9] Rau B, UHL W, BUCHLER M W. Surgical treatment of infected necrosis. 1997(2). doi:10.1007/s002689900208
[10] MEDICH D S, LEE T K, MELHEM M F. Pathogenesis of pancreatic sepsis. 1993(1). doi:10.1016/S0002-9610(5)80403-9
[11] Arendt T, WENDT M, OLSZEWSKI M. Cerulein-induced acute pancreatitis in rats-does bacterial translocation occur via a transperitoneal pathway?. 1997(3). doi:10.1097/00006676-199710000-00012
[12] Folch E, CLOSA D, GELPI E. Effect of peritoneal and lymph ligature on systemic complications of experimental acute pancreatitis, 2000(5)
[13] Gloor B, SCHMIDTMANN A B, WORHI M. Pancreatic sepsis:prevention and therapy, 2002(3)
[14] Uhl W, ISENMANN R, BUCHLER M W. Infections complicating pancreatitis:diagnosing,treating,preventing, 1998(6)
[15] Kotani J, USAMI M, NOMURA H. Enteral mutrition prevents bacterial translocation but does not improves survival during acute pancreatitis, 1999
[16] MCLLAVE S A, SNIDER H, OWENS N. Clinical nutrition in pancreatitis, 1997(10)
[17] Foitzik T, KRUSCHEWSKI M, KROESEN A J. Does glutamine reduce bacterial translocation?A study in two animal models with impaired gut barrier. 1999(3). doi:10.1007/s003840050200
[18] Sahin M, YOL S, CIFTCI E. Does large-bowel enema reduce septic complications in acute pancreatitis?. 1998(4)
[19] Chen X, VALENTE J F, ALEXANDER J W. The effect of sennosides on bacterial translocation and survival in a model of acute hemorrhagic pancreatitis. 1999(1). doi:10.1097/00006676-199901000-00006
[20] Wu C, LI Z, Xiong D. An experimental study on curative effect of Chinese medicine qing yi tang in acute necrotizing pancreatitis. 中国中西医结合杂志1998(4)
[21] Hosokawa M, TSUKADA H, FUKUDA F. Therapeutic effect of basic fibroblast growth factor on experimental pancreatitis in rat. 2000(4). doi:10.1097/00006676-200005000-00006
[22] KOURIS G J, LIU Q, ROSSI H. The effect of glucagon-like peptide 2 on intestinal permeability and bacterial translocation in a necrotizing pancreatitis. 2001(6). doi:10.1016/S0002-9610(1)00635-3
[23] Liu Q, DJURICIN G, NATHAN C. The effect of epidermal growth factor on the septic complications of acute pancreatitis. 1997(1). doi:10.1006/jsre.1997.5069
[24] Takagi K, ISAJI S. Therapeutic efficacy of continous arterial infusion of an antibiotic and a protease inhibitor via the superior mesenteric artery for acute pancreatitis in an animal model. 2000(3). doi:10.1097/00006676-200010000-00010
[25] SIMSEK I, REFIK M, YASAR M. Inhibition of inducible nitric oxide synthase reduces bacterial translocation in a rat model of acute pancreatitis. 2001(3). doi:10.1097/00006676-200110000-00011
[26] GuJ, WANG Y, Gao D. Effect of abdominal lavage with Chinese drugs on bacterial translocation in acute hemorrhagic necrotizing pancreatitis in rats. 中国中西医结合杂志2000(8)