乙型肝炎患者甲状腺激素水平及其临床意义-东南大学学报医学版

乙型肝炎患者甲状腺激素水平及其临床意义

单位：东南大学医学院,附属南京第二医院,江苏,南京,210003

分类号：R512.62

出版年·卷·期（页码）：2003·22·第六期（412-414）

摘要：

目的:探讨不同病程乙型肝炎(乙肝)患者甲状腺激素水平变化的临床意义.方法:用放射免疫法测定83例不同病程乙肝患者、32例非乙肝传染病患者以及37例健康人的血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺激素(TSH)的水平,并作统计分析.结果:急性乙肝患者T4、FT4水平升高,慢性乙肝患者FT3、FT4、TSH水平降低,肝硬化患者T3、FT3、TSH水平降低,重症肝炎患者T3、FT3、FT4、TSH水平降低.结论:检测血清甲状腺激素水平可作为临床评估乙肝病情和预后的辅助指标.

Objective To investigate the change and the clinical significance of serum thyroid hormone levels in the patients of different durations of hepatitis B.Methods Serum concentrations of T 3, T 4, FT 3, FT 4, TSH were detected with radioimmunoassay (RIA) in 83 patients with different durations of hepatitis B, 32 patients with non-hepatitis B infectious diseases and 37 normal controls. Results Serum T 4 and FT 4 levels increased in patients with acute hepatitis B. Levels of FT 3, FT 4 and TSH decreased in patients with chronic hepatitis B. The concentrations of serum T 3, FT 3 and TSH decreased in patients with liver cirrhosis. Serum T 3, FT 3, FT 4 and TSH levels decreased in severe hepatitis patients. Conclusion Determining the concentrations of serum thyroid hormone might be used as an assistant index in evaluating the status of hepatitis B and the prognosis of the patients.

参考文献：

[1] Joseph M, TIBALDI M D, MARTIN I. Effet of nonthyroidal illness on thyroid function, 1985
[2] 王宝平, 王华雨, 朱白. T3、T4测定在肝病中的临床意义. 临床内科杂志1995(4)
[3] 毛峻岭, 陈毓钵, 夏东明. 肝硬化患者测定甲状腺激素的临床意义. 临床肝胆病杂志2001(2). doi:10.3969/j.issn.1001-5256.2001.02.017
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