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体描仪测定哮喘儿童和成人肺功能的临床意义
作者:杨莉 李海浪 高庆梅 王文建 王西华 林勇 刘文革 
单位:东南大学,附属中大医院,江苏,南京,210009
关键词:哮喘 肺功能 人体体积描记仪 儿童 成人 
分类号:R562.25, R448
出版年·卷·期(页码):2003·22·第六期(399-402)
摘要:

目的:探讨人体体积描记仪(人体体描仪)测定哮喘儿童和成人肺功能的临床意义.方法:采用人体体描仪测定哮喘发作期儿童及成人治疗前后的肺功能,比较第1秒用力呼气容积(FEV1)、用力呼气肺活量(FVC)、第1秒用力呼气容积占用力呼气肺活量比值(FEV1/FVC)、最大呼气流量(PEF)和用力呼气25%、50%肺活量时瞬间流量(FEF25%、FEF50%)等肺功能指标的变化幅度.结果:治疗前儿童和成人组PEF异常率分别为92.58%和86.36%,治疗后上述指标均有不同程度提高,差异显著(均为P<0.001);两组间肺功能变化幅度除PEF(P>0.05)外,FVC、FEV1、FEV1/FVC、FEF25%、FEF50%差异均有显著性(均为P<0.01).结论:采用人体体描仪进行肺功能测定有利于哮喘诊断和发作期病情评估,更适合于年长儿童肺功能指标的监测.

Objective   To evaluate the clinical significance of pulmonary function with auto-body plethysmograph in children and adults with asthma.Method  The pulmonary function of pretherapy and of post-treatment was evaluated with auto-body plethysmograph in children and adults with asthma, and the changes of forced expiratory volume in 1 sec (FEV  1),forced vital capacity (FVC),FEV  1/FVC,peak expiratory flow(PEF),forced mid-expiratory flow rate (FEF    25%,FEF    50%) were measured. Results  25 of 27 cases in children(92.58%) and 19 case of 22 adults   (86.36%) were abnormal in PEF before treatment. The values of FEV  1,FVC,FEV  1/FVC,FEF    25%,FEF    50% in post-treatment in both groups were increased significantly(P&lt;0.01). Conclusion   Determination on pulmonary function by auto-body plethysmograph is valuable on the diagnosis and treatment of asthma.

参考文献:

[1] 中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗及教育和管理方案). 中华结核和呼吸杂志2003(3)
[2] 全国儿科哮喘防治协作组. 儿童哮喘防治常规. 中华儿科杂志1998(12)
[3] Gern J E, EGGLESTON P A, SCHUBERTH K C. Peak flow variation in childhood asthma:a three-year analysis. 1994(4). doi:10.1016/0091-6749(94)90250-X
[4] Frischer T, MEINERT R, URBANEK R. Variability of peak expiratory flow rate in children:short and long term reproducibility. 1995(1). doi:10.1136/thx.50.1.35
[5] 贾巨才, 毛宝龄, 王长征. 哮喘缓解期肺功能测定的初步探讨, 1991(2)
[6] 吴美思, 杨宇路. 196例儿童支气管哮喘发作期的肺功能改变, 1999(1) 

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