唾液酸酶法及多胺法在诊断细菌性阴道病中的应用-东南大学学报医学版

唾液酸酶法及多胺法在诊断细菌性阴道病中的应用

单位：东南大学,临床医学院,江苏南京,210009

分类号：R711.73, R446.19

出版年·卷·期（页码）：2003·22·第六期（391-392）

摘要：

目的:探讨唾液酸酶法及多胺法在诊断细菌性阴道病中的价值.方法:以Amsel诊断标准评价唾液酸酶法及多胺法的灵敏度和特异性.结果:唾液酸酶法灵敏度和特异性分别为89.2%与97.8%,多胺法分别为92.3%与86.7%;Amsel法中胺试验阳性率明显低于多胺法的阳性率(P<0.005);多胺法替代Amsel法中胺试验时,Amsel法的特异性和诊断效率分别为94.8%和96.0%.结论:唾液酸酶法检测快速、简便、可靠且便于质量控制,适合作为临床诊断的有效指标.多胺法作为单独的诊断方法其特异性略低,以其替代Amsel诊断标准中的胺试验有助于提高Amsel法的特异性和临床诊断效率.

Objective To study the value of sialidase and amines methods in the diagnosis of bacteria vaginosis(BV).Methods The two methods were evaluated according to Amsel criterion.Results In sialidase test,sensitivity was 89 2% and specificity was 97 8%. In amines test,sensitivity was 92 3% and specificity was 86 7%.The positive rate of whiff test was obviously lower than that of amines (P<0.005).When whiff test was replaced by amines test in Amsel test,specificity and the efficiency of diagnosis were respectively 94.8% and 96.0%.Conclusions Sialidase test in diagnosis of BV is rapid,simple,raliable and convenient for quality control,which is a suitable index in clinical diagnosis,while amines test itself is slightly less specific.The replacement of whiff test in Amsel test improves the specificity and efficiency of clinical diagnosis of BV.

参考文献：

[1] BRISELDEN A M. Sialidases (neuraminidases) in bacterial vaginosis and bacterial vaginosis-associated microflora, 1992(3)
[2] 李影林. 临床微生物学及检验, 1995
[3] Amsel R, TOTTEN P A, SPIEGAL C A. Nonspecific vaginitis:diagnostic criteria and microbial and epidemiological associations, 1983(1)
[4] 李云, 焦春梅, 韩玉华. 唾液酸酶测定对诊断细菌性阴道病价值的探讨. 华夏医学2002(6). doi:10.3969/j.issn.1008-2409.2002.06.005
[5] Eschenbach DA. History and review of bacterial vaginosis, 1993(2)

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