目的:探讨家兔被脑膜炎双球菌(MC)攻击后脾组织的病变特征.方法:模型组(n=10)耳缘静脉注射MC-A群菌株(按1×1011菌体*kg-1的剂量)复制成动物模型,对照组(n=8)予以等量的生理盐水.给药前及给药后60、120 min分别抽血检测血浆肿瘤坏死因子-α(TNF-α)浓度,120 min后处死动物,取脾作TNF-α细胞组织化学和超微结构检查.结果:模型组白髓内炎性及损伤的细胞周围有TNF-α沉积,脾索、脾窦、红细胞边缘也有TNF-α沉积,红细胞结构破坏,血浆TNF-α水平增高.对照组无异常.结论:MC攻击家兔后可导致TNF-α在脾内释放并引起损伤.

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