胰岛素信号转导与胰岛素抵抗-东南大学学报医学版

胰岛素信号转导与胰岛素抵抗

单位：1.东南大学,临床医学系98年级,江苏,南京,210009； 2.东南大学附属中大医院,内分泌科,江苏,南京,210009

分类号：Q735, R392.11, R458.5, R587.1

出版年·卷·期（页码）：2003·22·第四期（287-289）

摘要：

胰岛素通过与其受体结合可在不同组织细胞内激活不同的信号途径而产生不同的作用,因而信号转导的不同环节出现异常均可能导致胰岛素抵抗.近年来,胰岛素受体、胰岛素底物系列及磷脂酰肌醇-3-激酶等已成为在分子水平上研究胰岛素抵抗的热点.本文就这几方面文献报道作一综述.

Insulin combined with insulin receptor,can stimulate different signal transmission and induce different actions in cells of different tissues.So any kind of inhibition in insulin signaling may result in insulin resistance.Recently dysfunction of insulin receptor,insulin receptor substrates,PI?3K and so on,have become hot issues of the study on the molecular mechanism of insulin resistance.This paper is to review current literature on these topics.

参考文献：

[1] 李秀钧. 胰岛素抵抗综合征, 2001
[2] Kadowaki T. Insights into insulin resistance and type 2 diabetes from knockout mouse models. 2000(4). doi:10.1172/JCI10830
[3] Kido Y, BURBS D J, WITHERS D. Tissue-specific insulin resistance in mice with mutations in the insulin receptor,IRS-1,and IRS-2. 2000(2). doi:10.1172/JCI7917
[4] Hansen T, ANDEREN C B, ECHWALD S M. Identification of a common amino acid polymorphism in the P85 alpha regulatory subunit of phosphatidylinositol 3 kinase. 1997(3). doi:10.2337/diabetes.46.3.494
[5] 李洁, 李秀钧. 美国糖尿病学会第60届学术年会简况. 国外医学(内分泌学分册)2001(2). doi:10.3760/cma.j.issn.1673-4157.2001.02.016
[6] Walston J, SILVER K, BOGARDUS C. Time of onset of noninsulin-dependent diabetes mellitus and genetic variatio in the B3-adrenergic receptor gene. 1995(6). doi:10.1056/NEJM199508103330603
[7] Bloomgarden Z T. Insulin action and the development of type 2 diabetes. 2000(2). doi:10.2337/diacare.23.2.248
[8] Bloomgarden Z T. Genes and the cell biology of insulin secretion and insulin resistance. 1999(5). doi:10.2337/diacare.22.5.849
[9] MOHAMED ALI V, GOODRICK S, RAWESH A. Subcutaneous adipose tissue releases interleukin-6 but not tumor necrosis factor-α,in vivo, 1997(12)
[10] GRUPE A, ALLEMAN J, GOLDFINE I D. Inhibition of insulin receptor phosphorylation by PC-1 is not mediated by the hydrolysis of adenosine triphosphate or the generation of adenosine. 1995(38). doi:10.1074/jbc.270.38.22085
[11] Pizzuti A, FRITFITLA L, ARGIOLAS A. A potymorphism (k121Q)of the human ghycoprotein PC-1 gene coding region is strongly associated with insulin resistance. 1999(9). doi:10.2337/diabetes.48.9.1881
[12] 陈家伦. 胰岛素信号转导及临床意义. 国外医学(内分泌学分册)2002(1). doi:10.3760/cma.j.issn.1673-4157.2002.01.001
[13] Donnelly R, QU X. Mechanisms of insulin resistance and pharmacological approaches to metabolism and diabetic complications, 1998(2)

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