橄榄叶提取物对正常及糖尿病小鼠血糖和血脂水平的影响-东南大学学报医学版

橄榄叶提取物对正常及糖尿病小鼠血糖和血脂水平的影响

单位：1.中国药科大学,生物技术中心,江苏,南京,210009； 2.中国药科大学,生物技术中心,江苏,南京,210009;东南大学附属中大医院,检验科,江苏,南京,210009

分类号：R-332, R282.710.5, R446.112, R587.1

出版年·卷·期（页码）：2003·22·第四期（236-238）

摘要：

目的:观察橄榄叶提取物对正常及糖尿病小鼠血糖、血脂水平的影响.方法:给小鼠腹腔内注射链脲佐菌素建立糖尿病小鼠模型,观察橄榄叶醇提取物高、中、低剂量组对正常小鼠血糖的影响,橄榄叶醇提取物和酯提取物的高、中、低剂量组对糖尿病小鼠血糖、血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇的影响.结果:橄榄叶醇提取物的高、中剂量组对正常小鼠有明显降血糖作用.橄榄叶醇提取物及酯提取物的高、中、低剂量组均能降低糖尿病模型小鼠的血糖水平,且酯提取物的降血糖作用明显强于醇提取物.橄榄叶的酯提取物能对抗糖尿病模型小鼠血清中总胆固醇、甘油三酯和低密度脂蛋白胆固醇的升高.结论:橄榄叶提取物具有降血糖和调节血脂的作用.

Objective To investigate the effects of olive leaf extract on glycemia and lipidemia in normal and diabetic mice induced by steptozocin.Methods The living diabetic mice model was established by intra peritoneal injection of streptozocin.The effect of Et?OH fraction of olive leaf extract on blood glucose of normal mice was explored,so was the effect of Et?OH and Et?Oac fractions on blood glucose,serum total cholesterol,triglyceride and high and low-density-lipoprotein cholesterol of diabetic mice.Results Compared with the normal control group,the Et?OH fraction of high and middle doses could significantly decrease the blood glucose in normal mice.Both Et?OH and Et?Oac fractions could remarkably decrease the blood glucose in diabetic mice.In addition,hypoglycemic function of Et?Oac fraction was more obvious than that of Et?OH fraction.There was no manifest relationship between effects and doses.At the same time,it’s also shown that Et?Oac fraction could decrease the level of serum total cholesterol,triglyceride and low density lipoprotein cholesterol in diabetic mice.Conclusion Olive leaf extract can regulate blood glucose and the blood lipids.

参考文献：

[1] 董世林. 植物资源学, 1991
[2] PAIVA MARTINS F, GORDON M H. Isolation and characterization of the antioxidant component from olive leaves. 2001(9). doi:10.1021/jf010373z
[3] SAVOURNIN C, BAGHDIKIAN B, ELIAS R. Rapid HPLC analysis for the quantitative determination of oleuropein in olea europaea leaves. 2001(2). doi:10.1021/jf000596+
[4] GonzalezM, ZARZUELO A, GAMEZ M J. Hypoglycemic activity of olive leaf. 1992(6). doi:10.1055/s-2006-961538
[5] 张均田. 现代药理学实验方法, 1998
[6] 陈奇. 中药药理研究方法学, 1995
[7] 徐淑云, 卞如濂, 陈修. 药理实验方法学, 1994
[8] Junod A, LAMBERT A E, STAUFFACHER W. Diabetogenic action of streptozocin:relationship of dose to metabolic response. 1969(11). doi:10.1172/JCI106180
[9] 刘锡钧. 实用药物指南, 2000
[10] JI Y B. Pharmacological action and application of available composition of traditional Chinese medicine, 1995

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录