三氧化二砷(As2O3)是一种剧毒物质,它可以通过调控某些基因的表达和信号传导等途径来影响肿瘤细胞的生物活性.现已证实,As2O3在白血病尤其是急性早幼粒细胞白血病的治疗方面效果显著,其机制主要是诱导细胞凋亡.最近,一些基础研究表明, As2O3亦可诱导实体瘤细胞凋亡.所以,进一步拓展As2O3的抗瘤谱及药用价值是十分必要的.

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