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乙型肝炎病毒x基因与肝细胞肝癌
作者:曹基辉1 张静1 翟成凯1 钱耕荪2 
单位:1.东南大学公共卫生学院,江苏南京,210009; 2.上海市肿瘤研究所,上海,200032
关键词:乙型肝炎病毒 x基因 肝细胞肝癌 
分类号:R730.231, R735.7
出版年·卷·期(页码):2003·22·第三期(195-198)
摘要:

肝细胞肝癌(HCC)是我国常见的恶性肿瘤之一,其死亡率居我国癌症的第3位.乙型肝炎病毒(HBV)x基因具有相当广泛的功能,它的整合与HCC的形成密切相关.现就HBV x基因的结构、主要功能、在HCC中的表达、对p53及DNA修复蛋白的影响、对原癌基因的反式激活和作为癌基因直接诱导HCC几方面的研究进展进行综述.

Hepatocelluar carcinoma(HCC)is one of the common malignant tumors,and ranks the third in the death rate of all cancers in China.Gene   x   of hepatitis B virus(HBV) has broad functions,whose integration is closely related to the development of HCC.This paper makes a summary on the structure and main function of HBV gene   x  ,its expression in HCC,the influence on   p  53 and DNA repair protein, and its function as a transactivator to original cancer genes,as well as its direct inducement of HCC as a cancer gene.

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