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肿瘤坏死因子与充血性心力衰竭
作者:曹月新 徐标 
单位:东南大学附属中大医院,心血管内科,江苏,南京,210009
关键词:肿瘤坏死因子 充血性心力衰竭 心肌细胞 
分类号:R541.61
出版年·卷·期(页码):2003·22·第二期(133-136)
摘要:

肿瘤坏死因子(TNF)是一类促炎症细胞因子,现已证明TNF可由成熟的心肌细胞分泌产生,参与充血性心力衰竭(CHF)的病理生理过程,在抑制心肌收缩性,促进心肌重构,增加内皮、心肌细胞凋亡中起重要作用,针对CHF的抗TNF治疗研究尚处于尝试阶段,有待进一步评价.

Tumor necrosis factor (TNF) is a cytokine with proinflammatory properties.It has been proved that TNF,produced by mature cardiac myocytes,takes part in the pathophysiological process of congestive heart failure(CHF).It may play an important role in suppression of myocardial contractility,increasing endothelial cells,furthering ventricular remodeling and apoptosis of cardiac myocytes.Studies of anti?TNF therapy to CHF are still in progress which need further evaluation.

参考文献:

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