肾小球细胞与糖尿病肾病-东南大学学报医学版

肾小球细胞与糖尿病肾病

单位：1.东南大学附属中大医院,儿科,江苏,南京,210009； 2.东南大学基础医学院,病理学与病理生理学系,江苏,南京,210009

分类号：R587.2

出版年·卷·期（页码）：2003·22·第二期（125-128）

摘要：

在糖尿病肾病的发生发展过程中,高糖刺激肾小球固有细胞合成和分泌多种生物活性因子,而且肾小球固有细胞可以通过这些因子相互作用,导致肾多种细胞肥大、细胞外基质过度积聚,从而导致糖尿病肾病的特征性病理改变.联合使用这些生物活性因子的拮抗剂或抗体,将有助于防治糖尿病肾病.

In the development of diabetic nephropathy,high glucose stimulates the synthesis of many biological factors in intrinsic glomerular cells.Intrinsic glomerular cells can effect each other through these factors,leading to cell hypertrophy,EMC accumulation and diabetic glomerular sclerosis.The combination of inhibitors or antibodies of these factors can help us prevent and cure diabetic nephropathy.

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