PTEN和nm23-H1蛋白在乳腺癌组织中的表达及其临床意义-东南大学学报医学版

PTEN和nm23-H1蛋白在乳腺癌组织中的表达及其临床意义

单位：1.中国人民解放军第81医院,病理科,江苏,南京,210002;东南大学基础医学院,病理学与病理生理学系,江苏,南京,210009； 2.东南大学基础医学院,病理学与病理生理学系,江苏,南京,210009； 3.中国人民解放军第81医院,病理科,江苏,南京,210002

关键词：乳腺癌 10号染色体缺失且与张力蛋白同源物磷酸脂酶肿瘤转移抑制基因nm23-H1 预后

分类号：Q786, R737.9

出版年·卷·期（页码）：2003·22·第二期（89-92）

摘要：

目的:研究10号染色体缺失且与张力蛋白同源物磷酸脂酶(PTEN)、nm23-H1蛋白在乳腺癌组织中的表达并探讨其临床病理意义.方法:应用S-P免疫组织化学法检测70例乳腺癌组织中PTEN、nm23-H1蛋白表达水平.结果:乳腺增生性病变和良性肿瘤组织中PTEN呈高表达;远处转移组PTEN高表达率低于无转移组,两组间差异有显著意义(P<0.05).PTEN表达水平与患者年龄、肿瘤最大直径、淋巴结转移、组织学分级及类型无关,但在低年龄组和淋巴结转移组PTEN低表达率增高,有相关趋势.nm23-H1低表达者易发生转移复发(P<0.05).结论:同时检测PTEN、nm23-H1的蛋白表达对预测乳腺癌患者的复发和转移具有指导意义,两者均低表达的患者更容易复发.

Objective To study the expressions of PTEN and nm23?H 1 in breast carcinoma and their clinical significance.Method The expressions of those proteins was explored by immunohistochemistry S?P in 70 cases of breast carcinoma.Results High expression of PTEN was found in all proliferative lesions and benign tumor tissues.In distant metastasis group, high expression rate of PTEN has markedly declined(P<0.05).Expression of PTEN was not related to age,the maximum size of tumor histological grade and type and axillary lymph node metastasis.However,low PTEN expression has risen in lymph node metastasis group and that less than 45 years.Low level of expression of nm23?H 1 protein was significantly associated with lymphatic metastasis and recurrence.Conclusion Combined examination of PTEN and nm23?H 1 expression may be of significant clinical importance in the evaluation of the tendency of recurrence and metastasis.Patients whose PTEN and nm23?H 1 expression are low are liable to recuurence and metastasis.

参考文献：

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