近10年来的研究发现,胰腺炎时,胰腺中P物质水平及其受体NK-1R的表达均明显增加,与胰腺组织血浆外渗、损害程度以及慢性胰腺炎疼痛关系密切.作者就近年来一些相关文献作一综述,探讨P物质及其受体在胰腺炎发病机制中的作用.

[1] Chang M M, LEEMAN S E. Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P, 1970(18)
[2] GRADY E F, GARLAND A M, GAMP P D. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor, 1995(5)
[3] GRIESBACHER T, TIRAN B, LEMBECK F. Pathological events in experimental acute pancreatitis prevented by the bradykinin antagonist, 1993(2)
[4] McDONALD D M, THURSTON G, BALUK P. Endothelial gaps as sites for plasma leakage in inflammation. 1999(1). doi:10.1080/713773924
[5] GRADY E F, YOSHIMI S K, MAA J. Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice. 2000
[6] SALUJA A K, STEER M L P6. Pathophysiology of pancreatitis,Role of cytokines and other mediators of inflammation. 1999(Suppl 1). doi:10.1159/000051450
[7] Bhatia M, SALUJA A K, HOFBAUER B. Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. 1998(8). doi:10.1073/pnas.95.8.4760
[8] Maa J, GRADY E F, YOSHIMI S K. Substance P is a determinant of lethality in diet-induced hemorrhagic pancreatitis in mice. 2000(2). doi:10.1067/msy.2000.107378
[9] Dougherty P M, PALECEK J, PALECKOVA V. Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin, 1994(4)
[10] SHRIKHANDE S V, FRIESS H, di MOLA F F. NK-1 receptor gene expression is related to pain in chronic pancreatitis. 2001(3). doi:10.1016/S0304-3959(0)00436-X
[11] Maa J, GRADY E F, KIM E H. NK-1 receptor desensitization and neutral endopeptidase terminate SP-induced pancreatic plasma extravasation, 2000(4)
[12] TERASHIMA H, OKAMOTO A, MENOZZI D. Identification of neuropeptide-degrading enzymes in the pancreas. 1992(4). doi:10.1016/0196-9781(92)90181-2
[13] Hwang L, LEICHTER R, kamoto A. Downregulation of neutral endopeptidase(EC3.4.24.11.) in the inflamed rat intestine, 1993
[14] Sturiale S, BARBARA G, QIU B. Neutral endopeptidase(EC3.4.24.11) terminates colitis by degrading substance P, 1999(20)