Objective To explore the effect and safety of olanzapine.Methods 58 in-patients diagnosed as schizophrenia according to CCMD2R had been given olanzapine at least for 8 weeks.The dosage was 5mg·d -1 at the beginning.Afterwards,the dosage was adjusted according to clinical effect and side effect,and the maximum dosage was no more than 20mg·d -1.PANSS,CGI and TESS were evaluated before treatment and every other 2 weeks after treatment.Result PANSS total score and all factors score were significantly lower (P<0.01) in the end of treatment than in the beginning.The side effects were mainly antimuscarinic activity,somnolence,weight gain,transitory and reversible ALT increasing.Conclusion Olanzapine is one of the effective and safe antipsychotics. |