Objective To investigate the clinical feature of Wilson disease (WD) and to improve the early diagnosis of the disease.Method 92 patients with WD from 1989 to 2000 of the hospital were reviewed.Their clinical feature and misdiagnosis conditions were studied.Results 41 cases (44.57%) were misdiagnosed,38 cases (41.80%) failed to be diagnosed as other diseases,only 13 cases (14.13%) had been diagnosed as WD in early diagnose.The misdiagnosed rate was especially high when WD complicated with kidney and osteoarthrosis.The difference was not significant of the misdiagnosis rate between patients of different ages.Conclusion It is difficult to diagnose WD in early stage.Though it is decreasing,the misdiagnosed rate is still high.
参考文献:
[1] 王慕逖. 儿科学, 2000 [2] 梁秀龄. 肝豆状核变性研究的过去、现在和将来. 中国神经精神疾病杂志2001(2). doi:10.3969/j.issn.1002-0152.2001.02.001 [3] BONNE T B, FRYDMAN V, AGGER M S. Wilson's disease in Israel:a genetic and epidemiological study. 1990. doi:10.1111/j.1469-1809.1990.tb00372.x [4] YARZE J C, MARTIN P, MUNOZ S J. Wilson's disease:a review of misdiagnosed cases, 1995 [5] David P. Wilson's disease, 1984