缺氧缺血性脑病新生儿血浆PAF水平的变化及其临床意义-东南大学学报医学版

缺氧缺血性脑病新生儿血浆PAF水平的变化及其临床意义

单位：1.南京医科大学,附属南京儿童医院,江苏,南京,210008； 2.镇江医学院,临床检验系,江苏,镇江,212001

分类号：R722.1, R743.31, R977.6

出版年·卷·期（页码）：2002·21·第二期（171-173）

摘要：

目的:研究缺氧缺血性脑病(HIE)新生儿血浆血小板活化因子(PAF)水平变化,探讨PAF水平与HIE和脑损伤程度之间的关系.方法:采用生物学方法测定新生儿血浆PAF水平(40例为HIE组,10例正常新生儿为对照组).结果:中、重度HIE患儿急性期血浆PAF水平明显高于对照组(P<0.001),也明显高于恢复期血浆PAF水平(P<0.001);对照组血浆PAF水平与恢复期血浆PAF水平差异无显著性.结论:新生儿HIE血浆PAF水平变化与HIE和脑损伤的严重程度有关,PAF在新生儿缺氧缺血性脑损伤的发病机制中起重要作用.

Objective To study the changes of plasma PAF levels in neonatal hypoxic ischemic encephalopathy (HIE),and explore the relationship between PAF levels and severity of brain damage.Method The plasma PAF levels are measured in 40 neonates with HIE and 10 normal neonates by biological method.Results The serum level of PAF in acute HIE infants are significantly higher than that in normal infants ( P <0.001),and in particular are positively related to the severity of HIE.Conclusion The changes of plasma PAF levels in neonates with HIE is related to the severity of HIE and brain damage.It is suggested that PAF might play an important role in the pathogenesis of the brain damage of neonatal HIE.

参考文献：

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