人卵巢肿瘤组织中端粒酶活性表达及其临床意义-东南大学学报医学版

人卵巢肿瘤组织中端粒酶活性表达及其临床意义

单位：1.东南大学附属中大医院妇产科,江苏南京,210009； 2.江苏省肿瘤医院妇瘤科,江苏南京,210009

分类号：R737.31, Q55

出版年·卷·期（页码）：2002·21·第一期（69-71）

摘要：

目的:探讨卵巢肿瘤组织中的端粒酶活性表达及其临床意义.方法:采用TRAP-ELISA法检测21份卵巢肿瘤组织(其中恶性8份、良性13份)及4份正常卵巢组织标本中的端粒酶活性.结果:卵巢恶性肿瘤组织端粒酶活性表达阳性率为87.50%,显著高于卵巢良性肿瘤组织的7.69%,两者相比有显著性差异(P<0.05);正常卵巢组织阳性率为25.00%,与卵巢良性肿瘤组织相比无显著性差异(P>0.05).1例化疗后复发的卵巢浆液性乳头状腺癌,其端粒酶活性呈弱阳性.结论:端粒酶活性检测对于卵巢肿瘤的诊断及预后判断具有重要参考价值.

Objective To study the telomerase activity expression in human ovarian tumor tissues and its clinical significance.Method Telomerase activity was determined by using TRAP ELISA in ovarian tumor specimens,obtained from 21 women with ovarian tumors including 8 malignant,13 benign tumors and 4 normal ovarian tissues.Results The differences of telomerase activity expression in the tissues between the malignant ovarian tumors and the benign ovarian tumors were statistically significant( P <0.05),the differences between the malignant ovarian tumors and normal ovaries were statistically significant( P <0.05) as well,but the differences between the benign ovarian tumors and normal ovaries were not statistically significant( P >0.05).Telomerase activity in one case of recurrent ovarian serous papillary cystadenocarcinoma with chemical therapy was detected weak positive expression.Conclusions The detection of telomerase activity in ovarian tumors has an important reference value for the diagnosis and prognosis estimation.

参考文献：

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[6] Gorham H, YOSHIDA K, Sugino T. Telomerase activity in human gynaecological malignancies. 1997

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