肾移植长期存活受者细胞因子谱系的研究-东南大学学报医学版

肾移植长期存活受者细胞因子谱系的研究

单位：1.上海市第一人民医院； 2.上海市器官移植研究中心,上海,200080

分类号：R392.4

出版年·卷·期（页码）：2002·21·第一期（61-64）

摘要：

目的:通过细胞因子谱系,探讨长期维持不同剂量免疫抑制用药的肾移植受者的免疫学特征.方法:采用多种高灵敏度试剂盒,对存活3年以上,长期维持低剂量免疫抑制用药受者、常规剂量维持用药受者和慢性移植肾失功能受者的外周血多种细胞因子进行检测,分析细胞因子谱系的变化与临床用药量及移植效果的关系.结果:(1)白细胞介素4(IL-4)水平在长期存活、肾功能正常者中升高,尤其在低剂量组升高明显,而慢性肾功能减退者明显降低,(2)白细胞介素2受体(IL-2R)移植后升高,但低剂量组与正常人接近,功能减退组明显升高.(3)转化生长因子β1和白细胞介素10在移植后的3组病人中均下降,前者在低剂量受者和常规剂量受者中水平相近且下降最明显,后者以功能减退者下降最为明显.结论:细胞因子谱系与免疫抑制剂用量及移植肾功能有关,IL-2R和IL-4可用于评价移植受者的免疫状态,并有可能用作调整免疫抑制剂用量的参考指标.

Objective The purpose of the study was to investigate the immunological characteristics in long term renal transplant recipients at different dosage of immunosuppression.Methods The levels of cytokines in renal transplant recipients surviving more than 3 years at a low and a conventional dosages of immunosuppression (RLD group,RCD group) and in recipients with chronic allograft dysfunction (RCAF group) were detected by a high sensitive method.The relationships between the cytokine levels and the dosages of immunosuppression and allograft function were analyzed.Results 1.The level of IL?4 in RLD group increased significantly in comparison with that of RCD group.2.The level of IL?2R was similar to that of normal person in RLD group,but was much higher in RCAF group.3.The levels of TGF β 1 and IL?10 decreased in all recipients.Conclusion The levels of IL?4 and IL?2R can be used as parameters to evaluate the immunosuppressive status in long term renal transplant recipients and may be used to optimize immunosupprissive regime.

参考文献：

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