Objective  The experiment was designed to clear whether the autoimmune Meniere’s disease (AIMD) would be induced by the special humoral and/or cell  mediated  passive immunity against inner ear antigens,to inquire into the way of the special antibodies and lymphocytes against inner ear antigens to labyrinth and their position in it,and to study their effects on histology and physiological function of the inner ear.Methods  To establish AIMD animal (guinea pig) model,the antibodies (IgG) marked by fluorescence and T lymphocytes marked by   3?H were used for transmit immunity,immunized in local endolymphatic sac at the same time.The fluorescence reaction and the quantity of   3?H in different parts of membranous labyrinth were observed,and hearing and vestibular function measured.Results  The special antibodies against inner ear antigens firstly arrived at stria vascularis and endolymphatic sac,and the special lymphocytes against inner ear antigens appeared in endolymphatic sac first.A close correlation existed between the sensorineural hearing loss and vestibular dysfunction and the intensity of fluorescent reaction and the change of CPM value.Conclusions  The AIMD may be caused by the humoral and cell  mediated passive immunity against inner ear antigens.The special antibodies and lymphocytes against inner ear antigens could get to inner ear through blood circulation system.The immune inflammation was caused by the antibodies mainly through stria vascularis and endolymphatic sac,and the hydrolabyrinth by lymphocytes mainly through endolymphatic sac.