气道慢性炎症是变应性哮喘的基本特征,也是气道高反应性发生的病理基础.辅助性T淋巴细胞(Th细胞)之Th1细胞因子释放减少、Th2细胞因子上调表达导致体液免疫应答过强,是诱发慢性气道炎症的关键因素.白细胞介素-10具有抑制多种细胞(Th1、Th2、单核巨噬细胞)合成释放促炎性细胞因子的功能,并且参与气道高反应性的形成,其产生也受到炎性介质组胺等细胞因子外因素的调节.

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