P-gp和p53蛋白在大肠癌细胞中的表达及其临床意义-东南大学学报医学版

P-gp和p53蛋白在大肠癌细胞中的表达及其临床意义

单位：南京市第一医院病理科,

分类号：R735.34, Q754

出版年·卷·期（页码）：2001·20·第二期（114-115）

摘要：

目的：探讨大肠癌细胞中P-糖蛋白(P-gp)和p53蛋白的表达情况及其临床意义。方法：采用SP免疫组织化学法对64例大肠癌标本进行检测。结果：64例中有44例大肠癌标本的P-gp和p53蛋白表达一致，二者的表达有相关性；其中19例二者均为阳性表达，25例均为阴性表达，并且P-gp和p53蛋白在(Ⅲ加Ⅳ)组的阳性率显著高于(Ⅰ加Ⅱ)组。结论：大肠癌中P-gp和p53蛋白的表达密切相关，二者共同表达提示患者预后不良。

Objective To investigate the expression of P gp and p53 protein in colorectal carcinoma cells and their clinical significance.Methods 64 cases of colorectal carcinoma were examined by S P immunohistochemical method.Results The uniformity of P gp and p53 protein expression was found in 44 patients.Co expression of P gp and p53 was more frequently observed in group(Ⅲ+Ⅳ) than in group(Ⅰ+Ⅱ).Conclusion The expression of p53 protein is offen associated with P gp expression in colorectal carcinoma,co expression of P gp and p53 results in more aggressive phenotype,drug resistance and poor prognosis.

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