Objective To study the absorption,distribution and excretion process of clinafloxacin hydrochloride(CF) in rats.Methods The concentrations of CF in tissues and body fluids were determined by RP HPLC UV method after the rats had been administratered CF with the dosage of 5,10 and 20?mg·kg -1 through disgestive tract.Results and Conclusion The drug was found to conform to a one compartment model. t max was 1.0?h, t 1/2 was in the range of 2.03?h to 2.17?h.The relationship between dose and AUC or C max for CF was linear within the dosage range.CF was found in many organs after a single oral dose of 10?mg·kg -1 ,except brain and fat.After oral medication with 10?mg·kg -1 ,cumulative urinary excretion of CF was 20.6 %±7.81% in 72 h,cumlative feces excretion of CF was 0.98%±0.23% in 72 h,cumulative biliary excretion of CF was 0.43%±0.09% in 24 h.From 90.2% to 97.0% of CF in plasma was shown to be bound to protein. |
