Objective  To study the pathological changes of multiple organ function damage caused by coxsakie virus B  3 (CVB  3).Methods  20 healthy male BALB/C mice of 4～6 week  old were injected with 0.12?ml 10  9  TCID    50   CVB  3  virus li~quid into abdomen.The mice were killed 10 days later.The heart,live and lung were made into pathological section and pathological changes were observed through light microscope and electrotelescope.Result  17 mice had pathological change in heart and 2 of them had multiple organ damage (10%).Conclusion  CVB  3 infection may cause multiple organ damage,so the multiple organ damage in severe viral myocarditis should be paid attention to so as to improve the curability and livability.