黄芩甙对心肌梗死后大鼠免疫功能的调节作用-东南大学学报医学版

黄芩甙对心肌梗死后大鼠免疫功能的调节作用

单位：1.南京铁道医学院现代医学实验中心,江苏南京,210009； 2.南京铁道医学院现药理学研究室,江苏南京,210009

分类号：R542.2+2, R979.5

出版年·卷·期（页码）：2000·19·第三期（162-164）

摘要：

目的:通过测定心肌梗死后大鼠的T淋巴细胞亚群,观察心肌梗死后大鼠免疫功能的变化,同时观察黄芩甙对其免疫功能的调节作用.方法:结扎大鼠左冠脉前降支,饲养4个月后取血作淋巴细胞数及其亚群分析.结果:结扎冠脉4个月后,大鼠血液中CD3升高,但CD4/CD8值显著降低,表明心肌梗死后大鼠的免疫功能紊乱,细胞免疫功能明显降低.给予黄芩甙后(灌胃,40mg·kg-1·d-1),其血液中CD3、CD4/CD8均接近正常.结论:黄芩甙能改善心肌梗死后大鼠的免疫功能.

Objective To observe the immunomodulating effect of baicalin on the rats with chronic myocardial infarction.Methods The rat anterior descending branch of left coronary artery was ligated and then the rats was raised.After 4 months the hemodynamics and electrocardiogram were monitored. The blood sample was taken to assay levels of T lymphocyte subpopulations.The myocardium was taken to microscopical examination.Results The ratio of CD 4/CD 8 was markedly lowered in rats with ischemic heart failure. Baicalin was able to raise the ratio of CD 4/CD 8 to near normal, improved myocardial structure and the contractile function of heart.Conclusion Baicalin has cardioprotective effect possibly via immunomodulating effects.

参考文献：

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