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工业用蒽油对小鼠免疫功能影响的研究
作者:杨红 田世兰 高锦伍 韩小兵 邵蔚 罗成珠 吴沁 
单位:南京铁道医学院公共卫生学院,江苏南京,210009
关键词:工业用蒽油 淋巴细胞 免疫毒性 小鼠 
分类号:R114
出版年·卷·期(页码):2000·19·第三期(157-159)
摘要:

目的:为评价工业用蒽油对机体免疫功能的影响提供实验依据.方法:小鼠经消化道用工业用蒽油染毒2周,实验分设高、中、低3个剂量组和1个对照组,分别检测小鼠外周血T淋巴细胞的酸性α醋萘酚酯酶(ANAE)阳性率、淋巴细胞增殖功能及腹腔巨噬细胞的吞噬功能.结果:染毒剂量组外周血T淋巴细胞、淋巴细胞的OD值低于对照组,差异显著(P<0.05);染毒组的巨噬细胞吞噬率和吞噬指数低于对照组,差异不显著(P>0.05).结论:工业用蒽油对小鼠外周血T淋巴细胞的ANAE阳性率、淋巴细胞增殖具有一定的免疫毒性作用,对腹腔巨噬细胞吞噬功能的影响有待进一步研究.

Objective  The purpose of this study was to provide an experimental data on the immunotoxicity of industrial anthracene to mouse.Method  The animals were divided into 4 groups:a high  ,moderate  and low  dose group,and a control group.The total rate of T  lymphocytes in periphral blood,the proliferating ability of lymphocytes in spleen,and phagocytic rate and index of macrophages in abdominal cavity of the animal were detected after exposure to industrial anthracene for 2 weeks through disgestive tract.Results  The total rate of T  lymphocytes in periphral blood and an inhibited proliferation of lymphocytes in the exposes groups decreased significantly(  P  &lt;0.05).The phagocitic rate and index in the exposed groups were lower than those of control groups but no statistic significance was found(  P  &gt;0.05).Conclusion  Industrial anthracene can cause cell toxicity on lymphocytes.These results seem to indicate that industrial anthracene may possess potential hazard to the health of the exposed animal.

参考文献:

[1] 赵进顺, 高锦伍, 陈文娟. 蒽油的急性毒性及微核实验. 南京铁道医学院学报1994(4)
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