Objective  The purpose of this work was to analyze the changes in strains from infected burn wounds and the sensitivity to antibiotics by summing up germiculture of secretion from the wounds and drug sensitive test.Methods  The secretion or purulence from burn wounds of 345 patients hospitalized from 1984 to 1999 was taken within one week after admission and before changing dress.The secretion was inoculated and cultured at 35?℃ for 24 hours and identified routinely.And drug sensitive test by K  B method was performed at the same time. Results  538 strains from 345 infected burn patients included 27 species of bacteria and 3 species of fungi.The positive rates of Gram  positive and Gram  negative germ were   49.3  % and 48.1%,respectively.Of all isolated pathogens,there were 173 strains (32.2%)of   Staphylococcus aureus  ,and 152 strains (28.3%) of   Pseudomonas aeruginosa  .Conclusions  1.The dominant bacteria from the infected wounds are   Staphylococcus aureus   and   Pseudomonas aeruginosa  ,with the positive rate of the former being highest;2.The attention should be paid to the increased susceptibility of bacteria to antibiotics and the infection with methicillin  resistant staphy lococcus aureus(MRSA);3.The infection with some opportunistic pathogens and fungi was stressed;4.It is unavoidable for burn wounds to be effected by fungi  in plum rain season;5.It is necessary to use antibiotics reasonably.