IGF-I、EGF在糖尿病肾病中的变化及临床意义-东南大学学报医学版

IGF-I、EGF在糖尿病肾病中的变化及临床意义

单位：南京铁道医学院附属医院,内分泌科,江苏,南京,210009

分类号：R587.2

出版年·卷·期（页码）：2000·19·第二期（109-111）

摘要：

目的:观察糖尿病肾病患者不同病理时期血中胰岛素样生长因子.I(IGF.I)、尿中表皮生长因子(EGF)含量的变化,及其与糖化血红蛋白A1c(GHbA1c)、生长激素(GH)、病程的关系.方法:IGF.I、EGF、GH测定采用放射免疫法,GHbA1c测定采用微柱法.结果:早期糖尿病肾病者体内IGF.I、EGF水平较正常人升高;晚期糖尿病肾病者IGF.I、EGF水平较正常人明显下降.结论:IGF.I、EGF在糖尿病及糖尿病肾病的发生发展中起重要作用.

Objective The investigation was desinged to observe the changes in the serum levels of insulin like growth factor I(IGF?I),urinary excretion of epidermal growth factor(EGF) at different stages of diabetic nephropathy.Methods The levels of IGF?I and EGF were determined by radioimmunoassay.Results Serum IGF?I and urinary EGF levels significantly increased in early stage of diabetic nephropathy group compared to those of the normal control( P <0.01,0.05 repectively).On the other hand,the serum levels of IGF?I and urinary EGF were significantly decreased in late stage of diabetic nephropathy compared to those of the normal group( P <0.01,0.05 respectively).Conclusion IGF?I and EGF might be involved in the development of diabetes mellitus and diabetic nephropathy.

参考文献：

[1] 俞茂华, 孙佩, 方京冲. 糖尿病患者血清IGF.I水平与慢性并发症的关系, 1997(3)
[2] 林善锬. 重视糖尿病肾脏病变的诊断与治疗. 中华内分泌代谢杂志1998(2)
[3] Hwang D L, Lev-Ran A, Tay Y C. Epidermal growth factor excretion and receptor binding in diabetic rats, 1989(6)
[4] 沈克勤, 黎磊石, 杨俊伟. NIDDM肾病患者肾小管间质病变的研究, 1994(4)

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