雾化吸入肝素对致敏豚鼠血及肺组织组胺含量的影响-东南大学学报医学版

雾化吸入肝素对致敏豚鼠血及肺组织组胺含量的影响

单位：南京铁道医学院附属医院,呼吸内科,江苏,南京,210009

分类号：R976, R965

出版年·卷·期（页码）：2000·19·第二期（107-108）

摘要：

目的:观察吸入肝素对致敏豚鼠血、肺组织组胺含量的影响.方法:以卵蛋白作为抗原,激发豚鼠形成哮喘豚鼠模型,随机分成致敏组(A组)、给药组(B组)和对照组(C组),在卵蛋白雾化吸入后30 min、17 h测定血、肺组织组胺浓度.结果:致敏豚鼠吸入肝素后,再次接触抗原可抑制血、肺组织组胺浓度升高.结论:肝素抑制过敏反应可能和抑制肥大细胞释放组胺有关.

Objective The experiment was designed to research the effects of inhaled heparin on the the histamine concentration in lung tissue and blood of sensitized guinea pigs sensitized and challenged by ovalbumin.Method Sixty guinea pig models of asthma induced by ovalbumin were randomly allocated into three groups:sensitized,treated and control groups.The histamine concentration in lung tissue and blood of the guinea pigs was detected at 30 min and 17 h after inhalation of heparin.Result The histamine concentration in lung tissue and blood of the sensitized guinea pigs was decreased after inhaled heparin.Conclusion Heparin may play an inhibitory role in the histamine release by mast cells.

参考文献：

[1] 向军俭, 陈华粹. 组胺的荧光测定法的研究. 中国医学科学院学报1981
[2] Hutson P A, Church M K, Clay T P. Early and late.phase bronchoconstriction after allergen challenge of nonanesthetized guinea.pigs, 1988
[3] 谷伟, 孙丽华, 张祖贻. 吸入肝素对哮喘豚鼠气道炎症影响的研究. 中华结核和呼吸杂志1999(9)
[4] Ceyhan B, celikel T. Effect of inhaled heparin on methacholine induced bronchial hyperreactivity. 1995. doi:10.1378/chest.107.4.1009

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