多囊卵巢综合征患者应用二甲双胍增强氯米酚的促排卵效果观察-东南大学学报医学版

多囊卵巢综合征患者应用二甲双胍增强氯米酚的促排卵效果观察

单位：东南大学附属中大医院妇产科,江苏,南京,210009

分类号：R711.75

出版年·卷·期（页码）：2004·23·第六期（414-417）

摘要：

目的:探讨二甲双胍对耐氯米酚(CC)的多囊卵巢综合征(PCOS)患者的疗效.方法:选择耐CC的PCOS患者56例,分成A、B两组,采用随机、双盲、安慰剂控制试验.A组给二甲双胍500mg3次·d-1,月经第5～9天予安慰剂治疗;B组给二甲双胍500mg 3次·d-1,月经第5～9天予CC 50 mg 1次·d-1治疗.测定所有患者治疗前和治疗3个月后的性激素水平、空腹血糖(FG)、空腹胰岛素(FINS)以及胰岛素抵抗指数(HOMA-IR),B超监测排卵情况.结果:两组患者治疗后黄体生成素(LH)、睾酮(T)、FINS、HOMA-IR均明显下降(P＜0.001),B组排卵率明显优于A组(P＜0.001).结论:二甲双胍能使部分PCOS患者恢复排卵,二甲双胍和CC共同使用能明显提高耐CC的PCOS患者的排卵率.

Objective To observe the effect of metformin in th e treatment of patients with polycystic ovary syndrome (PCOS) who are resistant t o clomiphene citrate(CC). Methods In a double-blind, randomiz ed, placebo-controlled trail, 56 PCOS patients with CC-resi sta nt were randomly assigned into two groups. Patients in group A(n=28) randoml y received metformin 500-mg t.i.d and a placebo on day 5th-9th of menstruation . Group B(n=28) was rand omized to receive metformin 500-mg t.i.d with CC 50-mg q.d on day 5th-9th of menstruation.The d uration of the study was 3 months. The levels of serum FSH,LH T, glucose and i nsuli n at fasting (FG and FINS) were measured in all-patients. Transvaginal-ultraso nography was used for monitoring .Results IngroupA and B ,the levels of serumLH ,T ,FIN Sand HOMA IRweresignificantlyde creasedwhencomparedwiththoseofpre treatmentlevels(P <0.001) .The ovulationrateingroupBwereremarkablyhigher thanthatingroupA(P <0.01) .Conclusions Met for minthe rapyinwomen with PCOS can induce ovulation .Met for minplus CC ovulation is very effective in the treatment of CC-resistant PCOS .

参考文献：

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