Objective  To explore the effects of operation com b ined with chemotherapy for osteogenic sarcoma. Methods   A retro spective analysis  was performed on 51 patients with osteogenic sarcoma treated by limb-preserving  surgery or amputatio n. Thirty-two patients were treated by devitalization and replantation after lo cal arterial p erfusion or intrinsic resection and curettage with devitalization, 19 by amputa t ion. Chemotherapy was given for 6 cycles before and after operation. Res ults  For devitalization and replantation after local arterial perfusion  or intrinsic resecti on and curettage with devitalization, the average postoperative 3-,5-year  survival rate was 53.1%, 37.5%, respectively in 32 patients with osteogenic  sarc oma. Compared with the 19 patients who had amputation owing to osteogenic sarcom a in the same duration, there was no obvious difference of the postoperative 3 - ,5-years survive rate (P>0.05). And also no obvious difference of the 3- ,5 -year survival rates between the two kinds of limb preserving surgery (P>0. 05). The local recurrence rate was 6.25% of limb preserving surgery.  Conclusion  The long term results are the same  in the treatment  of osteogenic sarcoma by limb preserving surgery or amputation, and there are s o me advantages in intrinsic resection and curettage with devitalization, such as  keep ing the original contour and continuity of bone and joint, retaining partial fu n ction of the injured joint, performing easily, less complications and less exp ense.