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移植物抗肿瘤效应及其在实体瘤治疗中的意义
作者:翟光林 姜藻 
单位:东南大学临床医学院,江苏,南京,210009
关键词:造血干细胞移植 移植物 肿瘤/治疗 淋巴细胞输注 综述文献 
分类号:R-05, R617, R730.5
出版年·卷·期(页码):2004·23·第四期(282-285)
摘要:

异基因造血干细胞移植(Allo-HSCT)因具有独特的移植物抗恶性病效应常用来治疗某些恶性血液病,近年来Allo-HSCT在临床上尝试性地用来治疗某些实体瘤并取得了一定的疗效,现就Allo-HSCT所具有的移植物抗肿瘤效应及其免疫机制以及对实体瘤所产生的影响方面的文献报道作一综述.

Allogeneic hematopoietic stem cell transplantation(Allo-HSCT) has proved to have a unique immune-mediated antitumor effect in patients with hematologic malignancies. However,recently more investigators have come to recognize that antineoplastic effect mediated by immunopotent donor T-cells transplanted with the stem cell allograft can be induced against solid malignancies and achieved some therapeutic effect.This article reviews the graft-versus-tumor effect and its immunotherapeutic mechanism to investigate the potential of allogeneic immunotherapy for treating solid tumor.

参考文献:

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