乙胺嘧啶对雄性大鼠抗生育作用的实验研究-东南大学学报医学版

乙胺嘧啶对雄性大鼠抗生育作用的实验研究

单位：1.四川大学华西医院泌尿外科,四川,成都,610041;东南大学附属中大医院泌尿外科,江苏,南京,210009； 2.四川大学华西医院泌尿外科,四川,成都,610041； 3.东南大学附属中大医院泌尿外科,江苏,南京,210009

分类号：R979.2, R169.4

出版年·卷·期（页码）：2004·23·第四期（211-214）

摘要：

目的:研究乙胺嘧啶的抗生育作用及其可逆性.方法:通过给SD雄性大鼠灌服不同剂量乙胺嘧啶50 d后,观察其睾丸和附睾质量及组织学形态、附睾尾部精子活率和畸形率、血清睾酮含量、雄鼠的致孕率变化.结果:150 mg*(kg*d)-1组变化最明显,睾丸质量和脏器系数下降,睾丸曲细精管生精细胞排列疏松和结构紊乱,附睾上皮细胞肿胀和纤毛脱落,致孕率显著下降,实验各组附睾尾部精子存活率和畸形率均有下降,但血清睾酮含量没有显著变化.结论:乙胺嘧啶对睾丸生精过程和附睾上皮功能有影响,但不影响血清睾酮的分泌.

Objective To carry out a preliminary observation on contraceptive effect of pyrimethamine on male rats.Methods After fifty days of administration of pyrimethamine to male SD rats,functional parameters were observated including the weights and configurations of testis and epididymis,rates of sperm survival and deformation,content of serium testosterone and the pregnancy rate.Results Organ coefficient of testis and the pregnancy rate decreased prominently in the group receiving pyrimathamine of 150?mg·(kg·d) -1.The convoluted tubules of testis degenerated in various degrees. Stereocilia of epididymis epithelial cells exfoliated largely.Sperm survival and deformation declined in caudal epididymis without any changes of serum testerone content.Conclusion Pyrimethamine can influence testis spermatogenesis and function of epididymis epithelia.

参考文献：

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