>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
DNA甲基化与肿瘤
作者:叶覃 张建琼 谢维 
单位:东南大学基础医学院,遗传学研究中心,江苏省基因诊断与治疗重点实验室,"HLA表达与肿瘤"国际参考实验室,江苏,南京,210009
关键词:DNA甲基化 肿瘤 综述 
分类号:R730.231, R394
出版年·卷·期(页码):2004·23·第二期(136-140)
摘要:

DNA甲基化是一种重要的基因调控方式,DNA甲基化水平的改变在肿瘤的发生、发展中有重要的作用,DNA甲基化改变引起细胞中C→T突变、癌基因的低甲基化、抑癌基因的高甲基化、错配修复基因异常以及诱导染色体不稳定从而导致肿瘤的发生,利用肿瘤发生中DNA甲基化特征可对其进行有效的治疗.

DNA methylation is an important way of regulation of gene expression.Alteration of DNA methylation may play an important role in human tumor’s occurrence and development.The change of DNA methylation offen induce change of the Cytosine to Thymine,hypomethylation of oncogene,hypermethylation of tumor suppression gene,abnormality of mismatch repair gene and disstablity of chromosome which may promote different organism to come into malignant tumors.Studies of DNA methylation characteristics will be useful in tumors therapy.

参考文献:

[1] LAIRD W P, JAENISCH R. The role of DNA methylation in cancer genetics and epigenetics. 1996(). doi:10.1146/annurev.genet.30.1.441
[2] Jones P A, TAKAI D. The role of DNA methylation in mammalian epigenetics. 2001(5532). doi:10.1126/science.1063852
[3] Antequera F, BIRD A. Number of CpG islands and genes in human and mouse, 1993(24)
[4] Robertson K D, JONES P A. DNA methylation: past p resent and future directions. 2000(3). doi:10.1093/carcin/21.3.461
[5] Santini V, KANTARJIAN H M, Issa J P. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. 2001
[6] Deng D, El-RIFAI W, J I J. Hypermethylation of metallothionein- 3 CpG island in gastric carcinoma. 2003(1). doi:10.1093/carcin/24.1.25
[7] Rocco J W, SIDRANSKY D. P16 (MTS21/CDKN2/INK4a) in cancer progression. 2001. doi:10.1006/excr.2000.5149
[8] 陆娟, 房静远, 陈萦晅. 癌相关基因在结肠癌中的表达及其甲基化调控. 肿瘤2003(4). doi:10.3781/j.issn.1000-7431.2003.04.009
[9] MANCINI D N, RODENHISER D I, AINSWORTH P J. CpG methylation within the 5'regulatory region of BRCAL genies tumor specific and includes a putative CREB binding site. 1998(9). doi:10.1038/sj.onc.1201630
[10] MOMPARLER R L, BOVENZI V. DNA methylation and cancer. 2000(2)
[11] Nan X, NG H H, JOHNSON C A. Transcriptional repression by the methy1 CpG binding protein MeCP2 involves a histonedeacetylase complex. 1998(6683). doi:10.1038/30764
[12] Baylin S B, MAKOS M, Wu J J. Abnormal patterns of DNA methylation in human neoplasia: Potential consequences for tumor progression, 1991(10)
[13] DEHISSENKO M F, CHEN J X, TANG M S. Cytosine methylation determines hot spots of DNA damage in the human P53 gene. 1997(8)
[14] Rao P M, ANTONY A, RAJALAKCHMI S. Studies on hypomethylation of liver DNA during early stage of chemical carcinogenesis in rat liver. 1989. doi:10.1093/carcin/10.1.27
[15] Ohtsuki T, NISHITANI K, HATAMOCHI A. Analysis of methylation the c-myc gene in five human myeloma cell lines. 1991(2). doi:10.1111/j.1365-2141.1991.tb07973.x
[16] Sharrard R M, ROYDS J A, ROGERS S. Patterns of methylation of the c-myc gene in human colorectal cancer progression, 1992(5)
[17] 许琳, 罗兵, 王青. 胃癌MAGE-1基因启动子 B′B区去甲基化状态的研究. 中国肿瘤生物治疗杂志2003(1). doi:10.3872/j.issn.1007-385X.2003.01.010
[18] Ray J S, HARBISON M L, MCCLAIN R M. Alterations in the methylation status and expression of the raf oncogene in phenobarbital-induced and spontaneous B6C3F1 mouse liver tumors. 1994. doi:10.1002/mc.2940090307
[19] Greger V, DEBUS N, LOHMANN D. Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma. 1994(5). doi:10.1007/BF00211013
[20] Sakai T, TOGUCHID A J, OHTAN I N. Allele-dpecificc hypermethylation of the retinoblastoma tumor-suppressor gene, 1991(5)
[21] 张艳玲, 肖文华, 张艳梅. 肝细胞癌中p16基因及其甲基化的检测与意义. 第三军医大学学报2002(10)
[22] Ficorella C, CANNITA K, RICEVUTO E. P16hypermethylation contributes to the characterization of gene in activation profiles inprimary gastric cancer, 2003(1)
[23] Chim C S, LIANG R, TAM C Y. Methylation of p15and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance. 2001(7)
[24] WHEELER J M, BECK N E, KIM H C. Mechanisms If inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1. 1999(96). doi:10.1073/pnas.96.18.10296
[25] Nakajima T, AKIYAMA Y, SHIRAISHI J. Age-related hypermethylation of the hMLH1 promoter in gastric cancers. 2001(2). doi:10.1002/ijc.1454
[26] Chen R Z, PETTERSSON V, BEARD C. DNA hypomethylation leads to elevated mutationrates. 1998(6697). doi:10.1038/25779
[27] Lengauer C, KINZLER K W, Vogelstein B. DNA methylation and genetic instability in colorectal cancer cells. 1997(6)
[28] ALMEIDA A, KOKALJ-VOKAC N, LEFRANCOIS D. Hypomethylation of classical satellite DNA and chromosome instability in lymphoblastoid cell lines. 1993(6). doi:10.1007/BF00205077
[29] Schuffenhauer S, BARTSCH O, Stumm M. DNA FISH and complementation studies in ICF syndrome:A hypomethylation of repetitive and single copy loci and evidence for a trans acting factor. 1995(5). doi:10.1007/BF00197412
[30] Ferrone S, FINERTY J F. HLA class I antigen downregulation in human cancers: T-cell immuotherapy revives an old story. 1999. doi:10.1016/S1357-4310(99)01451-3
[31] Shen Y Q, WANG X C, Zhang J Q. HLA Class I antigen done-regulation in Gastric Cancer in the Jiansu Province China, 2002(zk)
[32] LEE K W, SHIN J Y, Lee J Y. Expression defect of an HLA-A * 24 allele associated with DNA methylation in a normal individual. 2003(4). doi:10.1034/j.1399-0039.2003.00044.x 

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 465081 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-83272481 83272483
电子邮件:
bjb@pub.seu.edu.cn

本系统由北京博渊星辰网络科技有限公司设计开发 技术支持电话:010-63361626

苏ICP备09058364