纳米科学与技术是近年来迅速发展起来的前沿科技领域,并已在各学科的研究中产生了巨大的影响.目前,纳米科学与技术在医药领域的应用也取得了令人瞩目的成绩,有力地推动了医药科技的发展;其在医学和药学方面为疾病的诊断与治疗开辟了一个崭新的领域.本文就纳米药物的概念和特点、制备方法和应用等作一综述,对相关技术和方法进行评价和展望,并简要介绍我国近年来纳米中药的研究与进展.

[1] 顾宁, 付德刚, 张海黔. 纳米技术与应用, 2002
[2] 平其能. 纳米药物和纳米载体系统. 中国新药杂志2002(1)
[3] 张磊, 平其能, 郭健新. 口服胰岛素纳米脂质体的制备及其降血糖作用. 中国药科大学学报2001(1)
[4] 杨时成, 朱家壁, 梁秉文. 喜树碱固体脂质体纳米粒的研究. 药学学报1999(2)
[5] MUHLEN A Z, MEHNERT W. Drug release and release mechanism of prednisolone loaded solid lipid nanoparticles, 1998(8)
[6] 张惠宏, 胡富强, 袁弘. 溶剂扩散法制备丙酸倍氯米松固体脂质纳米粒. 药学学报2003(4)
[7] Maria M G, BLANCO K, CRUZE M E M. Formulation of L-asp aragrnase-loaded PLGA nanoparticles: in fluence of polymerproperties on enzyme loading activity and in vitro release. 1998(52). doi:10.1016/S0168-3659(97)00196-X
[8] LI Y P, PEI Y Y, Zhang X Y. PEGylated PLGA nanoparticles as protein carriers: synthesis preparation and biodistribution in rats. 2001(2). doi:10.1016/S0168-3659(1)00218-8
[9] Bogunia-Kubik K, SUGISAKA M. From molecular biology to nanotechnology and nanomedicine. 2002(2-3). doi:10.1016/S0303-2647(2)00010-2
[10] MITRA S, GAUR U, GHOSH P C. Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanopartieals as carrier. 2001(1-3). doi:10.1016/S0168-3659(1)00342-X
[11] Davis S S. Biomedical applications of nanotechnology-implications for drug targeting and gene therapy. 1997. doi:10.1016/S0167-7799(97)01036-6
[12] LANZA G M, YU X, WINTER P M. Targeted antipro liferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agents: implications for rational therapy of restenosis. 2002(22). doi:10.1161/01.CIR.0000044020.27990.32
[13] Zhang Z R, GONG Y, Huang Y. Conjugation of mitoxantrone-loaded nanospheres and anti-C-erbB-2 monoclonal antibodies. 药学学报2001(2)
[14] Na K, BUM LEE T, PARK K H. Self-assembled nanoparticles of hydrophobically-modified polysaccharide bearing vitamin H as a targeted anti-cancer drug delivery system. 2003(2). doi:10.1016/S0928-0987(2)00257-9
[15] Gelperina S E, KHALANSKY A S, SKIDAN I N. Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma. 2002(2). doi:10.1016/S0378-4274(1)00456-8
[16] Kong G, BRAUN R D, DEWHIRST M W. Hyperthermia enables tumor-specific nanoparticle delivery:effect of particle size, 2000(16)
[17] I TO A, SHINKAI M, Honda H. Heat-inducible TNF-alpha geng therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy. 2001(8). doi:10.1038/sj.cgt.7700357
[18] Josephson L, TUNG C H, MOORE A. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. 1999(2). doi:10.1021/bc980125h
[19] Brigger I, DUBERNET C, COUVREUR P. Nanoparticles in cancer therapy and diagnosis. 2002(5). doi:10.1016/S0169-409X(2)00044-3
[20] 李先红. 非离子表面活性剂在纳米药物制备中的应用. 襄樊学院学报2002(5). doi:10.3969/j.issn.1009-2854.2002.05.019
[21] Chen D B, YANG T Z, LU W L. In vitro and in vivo study of two kinds of long-circulating solid lipid nanoparticles containing paclitaxel. 药学学报2002(1)
[22] OLIVA M, DIEZ-PEREZ I, GOROSTIZA P. Self-assembly of drug-polymer complexes: a spontaneous nanoencapsulation process monitored by atomic force microscopy. 2003(1). doi:10.1002/jps.10276
[23] 徐辉碧, 杨祥良, 谢长生. 纳米技术在中药研究中的应用. 中国药科大学学报2001(3)
[24] 张东生, 贾秀鹏, 樊祥山. 砒霜磁性纳米微球的研制及表征. 电子显微学报2002(5). doi:10.3969/j.issn.1000-6281.2002.05.021