>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
肿瘤疫苗及其增强策略
作者:王立新1 熊思东2 
单位:1.东南大学基础医学院,病原生物学和免疫学系,江苏,南京,210009; 2.东南大学基础医学院,病原生物学和免疫学系,江苏,南京,210009;复旦大学上海医学院,免疫学系,上海,200032
关键词:肿瘤 生物治疗 疫苗 
分类号:R457.2, R730.51
出版年·卷·期(页码):2004·23·第二期(125-130)
摘要:

肿瘤疫苗是利用肿瘤抗原激发机体自身的免疫保护机制达到防治肿瘤的目的,近来肿瘤疫苗已发展成为一种重要的肿瘤生物治疗手段.本文根据肿瘤疫苗的常见种类,从细胞载体肿瘤疫苗、肿瘤多肽疫苗、肿瘤基因疫苗以及抗独特型抗体肿瘤疫苗等方面对肿瘤疫苗的设计原理、增强策略的研究进展作一综述.

Objective  Increasing data recently showed that anti  tumor vaccine had become an important biotherapy for cancer.The common anti  tumor vaccines are classified as the cell  based tumor vaccines,antigen/peptide  based vaccines,DNA vaccines and anti  idiotype vaccines by their characteristics and preparations.This review summarizes and evaluates the advances in the research about the molecular design and immunoresponse  enhancing strategy of these anti  tumor vaccines.

参考文献:

[1] Saha A, CHATTERJEE S K, FOON K A. Murine dendritic cells pulsed with an anti-idiotype antibody induce antigenspecific protective antitumor immunity. 2003(11)
[2] MEIJER S L, DOLS A, URBA W J. Adoptive cellular therapy with tumor vaccine draining lymph node lymphocytes after vaccination with HLA-B7/beta2-microglobulin gene-modified autologous tumor cells. 2002(4)
[3] Salgia R, LYNCH T, SKARIN A. Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. 2003(4). doi:10.1200/JCO.2003.03.091
[4] Dakappagari N K, PYLES J, PARIHAR R. A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses. 2003(8)
[5] Pertl U, WODRICH H, RUEHLMANN J M. Immunotherapy with a posttranscriptionally modified DNA vaccine induces complete protection against metastatic neuroblastoma. 2003(2)
[6] Lou D, KOHLER H. Enhanced molecular mimicry of CEA using photoaffinity crosslinked C3d peptide. 1998(5). doi:10.1038/nbt0598-458
[7] Antonia S J, SEIGNE J, DIAZ J. Phase I trial of a B7-1 (CD80) gene modified autologous tumor cell vaccine in combination with systemic interleukin-2 in patients with metastatic renal cell carcinoma. 2002(5)
[8] BRIONES J, TIMMERMAN J, LEVY R. In vivo antitumor effect of CD40L-transduced tumor cells as a vaccine for B-cell lymphoma. 2002(11)
[9] Asada H, KISHIDA T, HIRAI H. Significant antitumor effects obtained by autologous tumor cell vaccine engineered to secrete interleukin (IL)-12 and IL-18 by means of the EBV/lipoplex. 2002(5). doi:10.1006/mthe.2002.0587
[10] YEI S, BARTHOLOMEW R M, PEZZOLI P. Novel membrane-bound GM-CSF vaccines for the treatment of cancer :generation and evaluation of mbGM-CSF mouse B16F10melanoma cell vaccine. 2002(9). doi:10.1038/sj.gt.3301803
[11] Jang Y J, NAM S Y, KIM M S. Simultaneous expression of allogenic class Ⅰ MHC and B7.1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity. 2002(1)
[12] Qian H N, LIU C Z, CAO S J. The experimental study of ovarian carcinoma vaccine modified by human B7-1 and IFN -gamma genes. 2002(1). doi:10.1046/j.1525-1438.2002.01060.x
[13] BRIONES J, TIMMERMAN J M, PANICALLI D L. Antitumor immunity after vaccination with B lymphoma cells overexpressing a triad of costimulatory molecules. 2003(7)
[14] Rieger R, KIPPS T J. CpG oligodeoxynucleotides enhance the capacity of adenovirus-mediated CD154 gene transfer to generate effective B-cell lymphoma vaccines. 2003(14)
[15] NIKITINA E Y, CHADA S, MURO-CACHO C. An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53. 2002(9). doi:10.1038/sj.gt.3301670
[16] Okada H, POLLACK I F, LIEBERMAN F. Gene therapy of malignant gliomas:A pilot study of immunnzation with irradiated autologous glioma and dendritic cells admixed with IL-4 transduced fibroblasts to elicit an immune response. 2001(5). doi:10.1089/104303401300042528
[17] Panelli M C, WUNDERLICH J, JEFFRIES J. Phase 1 study in patient with metastatic melanima of immunization with dendritic cells presenting epitopes derived from the melanim-associated antigen MART-1 and gp100, 2000(4)
[18] Su Z, DANNULL J, HEISER A. Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. 2003(9)
[19] GongJ, AVIGAN D, CHE N D. Activation of antitumor cytotoxic T lymphocytes by fusion of human dendritic cells and breast carcinoma cells. 2000(6). doi:10.1073/pnas.050587197
[20] Kugler A, STUHLER G, WALDEN P. Regression of human metastatic renal cell earcinoma after vaccination with tumor cell-dendritic cells hybrids. 2000. doi:10.1038/73193
[21] MENG W S, BUTTERFIELD L H, Ribas A. Ration design of peptide-based tumor vaccines. 2002(7). doi:10.1023/A:1016497818471
[22] Wang X Y, CHEN X, MANJILI M H. Targeted immunotherapy using reconstitJuted chaperone complexes of heat shock protein 110 and melanoma-associated antigen gpl00. 2003(10)
[23] MICONNET I, KOENIG S, SPEISER D. CpG are efficient aduvants for specific CTL induction against tumor antigen-derived peptide, 2002(3)
[24] Davila E, CELIS E. Repeated administration of cytosinephosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity, 2000
[25] Sun X, HODGE L M, JONES H P. Co-expression of granulocyte-macrophage colony-stimulating factor with antigen enhances humoral and tumor immunity after DNA vaccination. 2002(9/10). doi:10.1016/S0264-410X(1)00476-5
[26] King C A, SPELLERBERG M B, Zhu D. DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma. 1998(11). doi:10.1038/3266
[27] Rice J, BUCHAN S, STEVENSON F K. Critical components of a DNA fusion vaccine able to induce protective cytotoxic T cells against a single epitope of a tumor antigen, 2002(7)
[28] KALAT M, KUPCU Z, SCHULLER S. In vivo plasmid electroporation induces tumor antigen-specific CD8 + T-cell responses and delays tumor growth in a syngeneic mouse melanoma model, 2002(19)
[29] TIMMERMAN J M, SINGH G, HERMANSON G. Immunogenicity of a plasmid DNA vaccine encoding chimeric idiotype in patients with B-cell lymphoma. 2002(20)
[30] BARAL R N, SAHA A, CHATTERJEE S K. Immunostimulatory CpG oligonucleotides enhance the immune response of anti-idiotype vaccine that mimics earcinoembryonic antigen, 2003(5)  

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 414841 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-83272481 83272483
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364