尼莫地平包合物的制备及其光解动力学研究-东南大学学报医学版

尼莫地平包合物的制备及其光解动力学研究

单位：1.南京大学,污染控制与资源化研究国家重点实验室,江苏,南京,210093;中国药科大学,分析化学教研室,江苏,南京,210009； 2.中国药科大学,分析化学教研室,江苏,南京,210009； 3.河南省高等学校,环境科学与工程重点实验室,河南新乡,453700； 4.南京大学,污染控制与资源化研究国家

关键词：尼莫地平 β-环糊精包合物气相色谱法光解动力学

分类号：R943, R961

出版年·卷·期（页码）：2004·23·第二期（82-85）

摘要：

目的:考察尼莫地平及其包合物的光解稳定性.方法:将尼莫地平及其固体包合物在光照下进行加速实验.应用气相色谱法-电子捕获检测器分离并测定尼莫地平及其β-环糊精包合物含量.结果:建立了气相色谱法分离尼莫地平及其光解产物的分析方法.在选定的条件下,尼莫地平及其光解产物得到分离.内标法测定了尼莫地平含量.β-环糊精-尼莫地平包合物能增强尼莫地平的抗光稳定性.结论:尼莫地平及其包合物的光解符合一级动力学方程,包合物可以延长尼莫地平的半衰期t1/2.将尼莫地平制备成β-环糊精-包合物是提高其稳定性的有效方法.

Objective To prepare inclusion compound of nimodipine and cyclodextrin by coprecipitation and to investigate the photolysis of nimodipine and its inclusion complexes.Methods Nimodipine and its solid inclusion compound was photodecomposed by accleration.GC?ECD was used for separation and determination of nimodipine and its photodecomposition product.Results A gas chromatographic (GC) method for the separation of nimodipine and its photodecomposition product has been established.Under given conditions,an GC method has been established for the separation and determination of nimodipine.Compared with the photostability of the drug substance,the photostability of nimodipine in the inclusion was more stable.Conclusion The behavior of photodecomposition of nimodipine and its β ?CD inclusion complex correlated with first order dynamic equation.Half time of nimodipine in β ?CD inclusion complex was increased.This is an efficient method to prepare the NIM?β?CD for enhancing the photostability of nimodipine.

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