Objective  To explore whether the autoimmune of anti  labyrinth tissues could cause inner ear disorders and dysfunction by observing the inner ear physiological function changes of offspring of female guinea pigs with autoimmune sensorineural hearing loss(ASHL).Methods  The pregnant guinea pigs were immunized with conspecific inner ear antigen(CIEAg).Then their hearing function was measured with EcochG(including cAP,CM),and their vestibular function was measured by electronystagmography(including spontaneous nystagmus and caloric test).At the same time,the specific antibodies against inner ear tissues antigens in serum were measured by ELISA in all female guinea pigs and their offsprings.Results  9 offsprings of ASHL female guinea pigs appeared specific antibodies against CIEAg in serum,3 had sensorineural hearing loss.No distinct inner ear dysfunctions and immune reaction abnormality were found in pregnant guinea pigs of non  ASHL group and control group and their offsprings.Conclusion  Some of the offsprings of ASHL female guinea pigs might manifest sensorineural hearing loss to different extent,which could be induced by autoimmune inflammation against inner ear tissue antigens with specific antibodies from their mothers through blood  placental barrier.This result suggests that the factor of autoimmune against inner ear tissue antigens could be one of pathogenic causes inducing non  heritage congenital sensorineural hearing loss.